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0PI4KB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePIK4CB
DescriptionPhosphatidylinositol 4-kinase beta (ec 2.7.1.67) (ptdins 4-kinase) (pi4kbeta) (pi4k-beta) (npik) (pi4k92).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (TAS)
0004430 1-phosphatidylinositol 4-kinase activity (TAS)
0006661 phosphatidylinositol biosynthesis (TAS)
0006898 receptor mediated endocytosis (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Phosphatidylinositol 3-kinase (PI3-kinase) () is an enzymethat phosphorylates phosphoinositides on the 3-hydroxyl group of the inositolring. The three products of PI3-kinase - PI-3-P.I-3.-P(2) and PI-3..-P(3) function as secondary messengers in cell signalling.Phosphatidylinositol 4-kinase (PI4-kinase) () is an enzymethat acts on phosphatidylinositol (PI) in the first committed step in theproduction of the secondary messenger inositol-1...trisphosphate. This domain is also present in a wide range of protein kinases.nvolved in diverse cellular functions.uch as control of cell growth.egulation of cell cycle progression. DNA damage checkpoint.ecombination.nd maintenance of telomere length. Despite significant homology to lipid kinases.o lipid kinase activity has been demonstrated for any of the PIK-related kinases . The PI3- and PI4-kinases share a well conserved domain at their C-terminalsection; this domain seems to be distantly related to the catalytic domain ofprotein kinases . The catalytic domain of PI3K has the typical bilobal structure that is seen in other ATP-dependent kinases.ith a small N-terminal lobe and a large C-terminal lobe. The core of this domain is the most conserved region of the PI3Ks. The ATP cofactor binds in the crevice formed by the N-and C-terminal lobes. loop between two strands provides a hydrophobic pocket for binding of the adenine moiety.nd a lysine residue interacts with the alpha-phosphate. In contrast to protein kinases.he PI3K loop which interacts with the phosphates of the ATP and is known as the glycine-rich or P-loop.ontains no glycine residues. Instead.ontact with the ATP -phosphate is maintained through the side chain of a conserved serine residue.
  IPR000403:Phosphatidylinositol 3- and 4-kinase, catalytic
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000403:PI3Kc 
Evalue:-104.309803919971 
Location:560-814IPR011009:Kinase_like 
Evalue:0 
Location:1-13
SequencesProtein: PI4KB_HUMAN (816 aa)
mRNA: AJ011123 NM_002651
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentK00888
  Level 3 annotation:
    phosphatidylinositol 4-kinase
  Level 2 annotation:
    Inositol phosphate metabolism
    Phosphatidylinositol signaling system
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 366 residues, 149531036-149532133Exon2: 42 residues, 149533117-149533238Exon3: 46 residues, 149533508-149533641Exon4: 90 residues, 149537907-149538173Exon5: 43 residues, 149540943-149541067Exon6: 37 residues, 149541293-149541398Exon7: 38 residues, 149542640-149542750Exon8: 78 residues, 149545235-149545463Exon9: 78 residues, 149546673-149546901Exon10: 17 residues, 149549310-149549355Exon11: 314 residues, 149554672-149555609Exon12: 27 residues, 149565271-149565348Exon13: 2 residues, -Jump to PI4KB_HUMANExon1: 301 residues, 149531231-149532133Exon2: 42 residues, 149533117-149533238Exon3: 46 residues, 149533508-149533641Exon4: 90 residues, 149537907-149538173Exon5: 43 residues, 149540943-149541067Exon6: 37 residues, 149541293-149541398Exon7: 38 residues, 149542640-149542750Exon8: 78 residues, 149545235-149545463Exon9: 78 residues, 149546673-149546901Exon10: 17 residues, 149549310-149549355Exon11: 314 residues, 149554672-149555609Exon12: 49 residues, 149566370-149566511Exon13: 2 residues, -Jump to PI4KB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2548 149493820-149506576 ~-13K 2556(PSMD4)(+)Loci: 3831 149531036-149566511 ~-35K 2560(PIK4CB)(-)Loci: 2549 149851285-149938183 ~-87K 2579(SNX27)(+)Loci: 3832 150010960-150029541 ~-19K 2590(TDRKH)(-)Loci: 3830 149370788-149385728 ~-15K 2543(SEMA6C)(-)Link out to UCSC