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0NPY4R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPYR1
DescriptionNeuropeptide y receptor type 4 (npy4-r) (pancreatic polypeptide receptor 1) (pp1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0008015 circulation (TAS)
0007586 digestion (TAS)
0007631 feeding behavior (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide Y (NPY) is one of the most abundant peptides in mammalianbrain.nducing a variety of behavioural effects (e.g..timulation of foodintake.nxiety.acilitation of learning and memory.nd regulation of thecardiovascular and neuroendocrine systems). In the periphery.PYstimulates vascular smooth muscle contraction and modulates hormonesecretion. NPY has been implicated in the pathophysiology of hypertension.ongestive heart failure.ffective disorders and appetite regulation .
  IPR000611:Neuropeptide Y receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Neuropeptide Y (NPY) is one of the most abundant peptides in mammalianbrain.nducing a variety of behavioural effects (e.g..timulation of foodintake.nxiety.acilitation of learning and memory.nd regulation of thecardiovascular and neuroendocrine systems). In the periphery.PYstimulates vascular smooth muscle contraction and modulates hormonesecretion. NPY has been implicated in the pathophysiology of hypertension.ongestive heart failure.ffective disorders and appetite regulation .Several pharmacologically distinct neuropeptide Y receptors have beencharacterised.esignated NPY Y1-Y6. Y4 receptors show highest similarityto Y1 receptors from human.at and mouse . It is believed that theymay have potential roles in central nervous system.ardiovascular andgastrointestinal function .
  IPR001933:Neuropeptide Y4 receptor
IPR000276:7tm_1 
Evalue:-60.7958793640137 
Location:58-322IPR001933:NRPEPTIDEY4R 
Evalue:0 
Location:2-17IPR001933:NRPEPTIDEY4R 
Evalue:0 
Location:359-373IPR001933:NRPEPTIDEY4R 
Evalue:0 
Location:19-32IPR001933:NRPEPTIDEY4R 
Evalue:0 
Location:34-47IPR001933:NRPEPTIDEY4R 
Evalue:0 
Location:345-358IPR001933:NRPEPTIDEY4R 
Evalue:0 
Location:329-340
SequencesProtein: NPY4R_HUMAN (375 aa)
mRNA: BC096237 NM_005972
Local Annotation
Synapse Ontology
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:domains)
long-term depression is the opposite to LTP. LTD means a decrease in the synaptic strength that could last for more than 5 mins. It is typically evoked by brief, strong stimulation.
sdb:0213 LTD  (Evidence:domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
components of the signal transduction machinery for LTP are all the molecules that are involved in the LTP transduction machinery.
sdb:0251 components of the signal transduction machinery for LTP  (Evidence:domains)
KO assignmentK04206
  Level 3 annotation:
    neuropeptide Y receptor Y4
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 69 residues, 46503539-46503743Exon2: 54 residues, 46505539-46505695Exon3: 533 residues, 46506730-46508325Exon4: 2 residues, -Jump to NPY4R_HUMANExon1: 484 residues, 46506729-46508179Exon2: 2 residues, -Jump to NPY4R_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2613 46503539-46508325 ~-5K 4831(PPYR1)(+)Loci: 3889 46375452-46391406 ~-16K 4826(-)Link out to UCSC