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0NOE3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionNoelin-3 precursor (olfactomedin-3) (optimedin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The olfactomedin-domain was first identified in olfactomedin.n extracellular matrix protein of the olfactory neuroepithelium . Members of this extracellular domain-family have since been shown to be present in several metazoan proteins.uch as latrophilins.yocilins.ptimedins and noelins.he latter being involved in the generation of neural crest cells. Myocilin is of considerable interest.s mutations in its olfactomedin-domain can lead to glaucoma . The olfactomedin-domains in myocilin and optimedin are essential for the interaction between these two proteins .
Signal transducing histidine kinases are the key elements in two-component signal transduction systems.hich control complex processes such as the initiation of development in microorganisms . Examples of histidine kinases are EnvZ.hich plays a central role in osmoregulation .nd CheA.hich plays a central role in the chemotaxis system . Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain.ut other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP.he phosphotransfer from the kinase to an aspartate of the response regulator.nd the phosphotransfer from aspartyl phosphate back to ADP or to water . The homodimeric domain includes the site of histidine autophosphorylation and phosphate transfer reactions. The structure of the homodimeric domain comprises a closed.our-helical bundle with a left-handed twist.ormed by two identical alpha-hairpin subunits.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009082:Histidine kinase, homodimeric
SequencesProtein: NOE3_HUMAN (478 aa)
mRNA: AF397393 AY358722 NM_058170
Local Annotation
Synapse Ontology
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 780 residues, 102040722-102043059Exon2: 37 residues, 102044219-102044326Exon3: 75 residues, 102063169-102063389Exon4: 54 residues, 102068815-102068971Exon5: 51 residues, 102075022-102075169Exon6: 83 residues, 102234891-102235136Exon7: 2 residues, -Jump to NOE3_HUMANExon1: 476 residues, 102041632-102043059Exon2: 37 residues, 102044219-102044326Exon3: 247 residues, 102050553-102051290Exon4: 75 residues, 102063169-102063389Exon5: 54 residues, 102068815-102068971Exon6: 51 residues, 102075022-102075169Exon7: 45 residues, 102084988-102085117Exon8: 2 residues, -Jump to NOE3_HUMANExon1: 445 residues, 102041725-102043059Exon2: 37 residues, 102044219-102044326Exon3: 75 residues, 102063169-102063389Exon4: 54 residues, 102068815-102068971Exon5: 51 residues, 102075022-102075169Exon6: 68 residues, 102084988-102085188Exon7: 2 residues, -Jump to NOE3_HUMAN  
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