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0MYP0_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMPZ
DescriptionMyelin p0 protein precursor (myelin protein zero) (myelin peripheral protein) (mpp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (NAS)
0005198 structural molecule activity (NAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda.ach composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha.elta.psilon.amma and mu.ll consisting of a variable domain (VH) and three (in alpha.elta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins.n which the variable and constant domains have clear.onserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ).1-set (constant-1; ).2-set (constant-2; ) and I-set (intermediate; ) . Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure.ith the types differing in the number of strands in the beta-sheets as well as in their sequence patterns .Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions.ncluding cell-cell recognition.ell-surface receptors.uscle structure and the immune system . This entry represents the V-set domains.hich are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families.ncluding immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2).D4.D80.nd CD86; in myelin membrane adhesion molecules; in junction adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1).
  IPR013106:Immunoglobulin V-set
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda.ach composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha.elta.psilon.amma and mu.ll consisting of a variable domain (VH) and three (in alpha.elta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins.n which the variable and constant domains have clear.onserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ).1-set (constant-1; ).2-set (constant-2; ) and I-set (intermediate; ) . Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure.ith the types differing in the number of strands in the beta-sheets as well as in their sequence patterns .Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions.ncluding cell-cell recognition.ell-surface receptors.uscle structure and the immune system . Ig-like domains can be classified according to the number of beta strands. The V-type is antibody variable domain-like.nd has two extra beta strands over the classical C1-type Ig-like domain. This subfamily includes Ig variable domains.yelin membrane adhesion molecules. cell surface glycoproteins.unction adhesion molecules (JAM).oxsackie virus and adenovirus Car receptors.nd viral haemagglutinin.
  IPR003596:Immunoglobulin V-set, subgroup
The myelin sheath is a multi-layered membrane.nique to the nervous system.hat functions as an insulator to greatly increase the velocity of axonal impulse conduction. The P0 glycoprotein.bsent in the central nervous system .s a major component of the myelin sheath in peripheral nerves. It comprises a large extracellular N-terminal domain. single transmembrane (TM) region.nd a smaller positivelycharged intracellular domain. It is postulated that P0 is a structural element in the formation and stabilisation of peripheral nerve myelin .olding its characteristic coil structure together by the interaction of its positively-charged domain with acidic lipids in the cytoplasmic face of the opposed bilayer.nd by interaction between hydrophobic globular heads of adjacent extracellular domains .
  IPR000920:Myelin P0 protein
The Epstein barr virus is a human herpes virus that is associated with several malignancies and diseases. Papillomaviruses infect epithelial cells.nd certain strains are associated with tumour formation. The EBNA-1 protein of Epstein barr virus and the E2 protein of papillomavirus both function to activate viral DNA replication. Despite a lack of sequence similarity between these two proteins.he core DNA-binding domain of the EBNA-1 protein shows structural homology to the entire DNA binding and dimerisation domain of the E2 protein. X-ray crystallography reveals the E2 and EBNA1 core DNA-binding domains to be comprised of an eight-stranded beta-barrel.lanked on two sides by two alpha helices . The differences between the E2 and EBNA1 structures occur in the loops and connections between the beta strands. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009021:Viral protein, DNA-binding
This entry represents domains with an immunoglobulin-like (Ig-like) fold.hich consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals.ccurring in a variety of different proteins. These domains are often involved in interactions.ommonly with other Ig-like domains via their beta-sheets . Domains within this fold-family share the same structure.ut can diverge with respect to their sequence. Based on sequence.g-like domains can be classified as V-set domains (antibody variable domain-like).1-set domains (antibody constant domain-like).2-set domains.nd I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example.n the human T-cell receptor antigen CD2.omain 1 (D1) is a V-set domain.hile domain 2 (D2) is a C2-set domain.oth domains having the same Ig-like fold .Domains with an Ig-like fold can be found in many.iverse proteins in addition to immunoglobulin molecules. For example.g-like domains occur in several different types of receptors (such as various T-cell antigen receptors).everal cell adhesion molecules.HC class I and II antigens.s well as the hemolymph protein hemolin.nd the muscle proteins titin.elokin and twitchin.
  IPR013783:Immunoglobulin-like fold
IPR013106:V-set 
Evalue:-23.8538722991943 
Location:29-147IPR009021:Viral_DNA_bd 
Evalue:0 
Location:182-244IPR000920:MYELINP0 
Evalue:0 
Location:155-179
SequencesProtein: MYP0_HUMAN (248 aa)
mRNA: BC006491 NM_000530
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK06770
  Level 3 annotation:
    myelin protein zero
  Level 2 annotation:
    Cell adhesion molecules (CAMs)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 185 residues, 159541150-159541703Exon2: 150 residues, 159541947-159542391Exon3: 22 residues, 159542521-159542582Exon4: 47 residues, 159542742-159542878Exon5: 73 residues, 159543121-159543335Exon6: 57 residues, 159543671-159543838Exon7: 40 residues, 159546252-159546368Exon8: 2 residues, -Jump to MYP0_HUMANExon1: 185 residues, 159541150-159541703Exon2: 150 residues, 159541947-159542391Exon3: 22 residues, 159542521-159542582Exon4: 47 residues, 159542742-159542878Exon5: 73 residues, 159543121-159543335Exon6: 57 residues, 159543671-159543838Exon7: 40 residues, 159546252-159546368Exon8: 2 residues, -Jump to MYP0_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2566 159402817-159407634 ~-5K 3130(PPOX)(+)Loci: 3843 159407724-159413938 ~-6K 3131(B4GALT3)(-)Loci: 2567 159435728-159450806 ~-15K 3135(NDUFS2)(+)Loci: 3844 159458706-159460042 ~-1K 3139(APOA2)(-)Loci: 3845 159541150-159546368 ~-5K 3155(MPZ)(-)Loci: 2568 159550789-159601157 ~-50K 3157(SDHC)(+)Loci: 2565 159354514-159357481 ~-3K 3121(NIT1)(+)Link out to UCSC