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0FAF1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFAF1
DescriptionFas-associated factor 1 (faf1 protein) (hfaf1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0031265 CD95 death-inducing signaling complex (NAS)
0005829 cytosol (IDA)
0005634 nucleus (IDA)
0048471 perinuclear region (IDA)
0031072 heat shock protein binding (IDA)
0030191 Hsp70/Hsc70 protein inhibitor activity (IDA)
0051059 NF-kappaB binding (IPI)
0019901 protein kinase binding (IDA)
0008605 protein kinase CK2 regulator activity (NAS)
0008219 cell death (IMP)
0007253 cytoplasmic sequestering of NF-kappaB (IMP)
0043065 positive regulation of apoptosis (NAS)
0031334 positive regulation of protein complex asse... (IMP)
0043161 proteasomal ubiquitin-dependent protein cat... (NAS)
0042176 regulation of protein catabolism (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
UAS is a domain of unknown function found in FAF1 proteins (FAS-associated factor 1) and in otherproteins.any of which are described as having no known function.
  IPR006577:UAS
The UBX domain is found in ubiquitin-regulatory proteins.hich are members of the ubiquitination pathway.s well as a number of other proteins including FAF-1 (FAS-associated factor 1).he human Rep-8 reproduction protein and several hypothetical proteins from yeast. The function of the UBX domain is not known although the fragment of avian FAF-1 containing the UBX domain causes apoptosis of transfected cells.
  IPR001012:UBX
IPR006577:UAS 
Evalue:-70.3767507096021 
Location:336-481IPR001012:UBX 
Evalue:-32.1426675035687 
Location:566-648
SequencesProtein: FAF1_HUMAN (650 aa)
mRNA: NM_007051
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 88 residues, 50679522-50679783Exon2: 74 residues, 50713723-50713939Exon3: 28 residues, 50728847-50728925Exon4: 29 residues, 50729980-50730061Exon5: 31 residues, 50773628-50773717Exon6: 47 residues, 50777851-50777988Exon7: 53 residues, 50805336-50805491Exon8: 29 residues, 50820877-50820959Exon9: 23 residues, 50821911-50821975Exon10: 44 residues, 50822944-50823071Exon11: 34 residues, 50834380-50834476Exon12: 31 residues, 50893701-50893788Exon13: 37 residues, 50944045-50944151Exon14: 32 residues, 50977122-50977214Exon15: 32 residues, 50982943-50983035Exon16: 70 residues, 51026259-51026465Exon17: 17 residues, 51039890-51039937Exon18: 25 residues, 51096188-51096257Exon19: 168 residues, 51198026-51198524Exon20: 2 residues, -Jump to FAF1_HUMANExon1: 83 residues, 50679535-50679783Exon2: 74 residues, 50713723-50713939Exon3: 28 residues, 50728847-50728925Exon4: 29 residues, 50729980-50730061Exon5: 31 residues, 50773628-50773717Exon6: 47 residues, 50777851-50777988Exon7: 53 residues, 50805336-50805491Exon8: 29 residues, 50820877-50820959Exon9: 23 residues, 50821911-50821975Exon10: 44 residues, 50822944-50823071Exon11: 34 residues, 50834380-50834476Exon12: 29 residues, 50893701-50893784Exon13: 38 residues, 50944041-50944151Exon14: 32 residues, 50977122-50977214Exon15: 32 residues, 50982943-50983035Exon16: 70 residues, 51026259-51026465Exon17: 17 residues, 51039890-51039937Exon18: 25 residues, 51096188-51096257Exon19: 122 residues, 51198026-51198388Exon20: 2 residues, -Jump to FAF1_HUMAN  
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