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0LSD1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAOF2 (Synonyms: BHC110|KIAA0601|LSD1)
DescriptionLysine-specific histone demethylase 1 (ec 1.-.-.-) (amine oxidase flavin containing domain protein 2) (aof2 protein) (braf35-hdac complex protein bhc110).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
This entry consists of various amine oxidases.ncluding maize polyamine oxidase (PAO) .-amino acid oxidases (LAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of theseenzymes.In vertebrates MAO plays an important role in regulating the intracellular levels of amines via their oxidation; these include various neurotransmitters.eurotoxins and trace amines . In lower eukaryotessuch as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium .PAOs in plants.acteria and protozoa oxidise spermidine and spermine to an aminobutyral.iaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines .Other members of this family include tryptophan 2-monooxygenase.utrescine oxidase.orticosteroid binding proteins and antibacterial glycoproteins.
  IPR002937:Amine oxidase
InterPro domains unassigned to SynO:
The SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in eukaryotic chromosomal proteins. It is named after the proteins SWI3.SC8 and MOIRA in which it was first recognised. This domain is predicted to mediate protein-protein interactions in the assembly of chromatin-protein complexes. The SWIRM domain can be linked to different domains.uch as the ZZ-type zinc finger ().he Myb DNA-binding domain ().he HORMA domain ().he amino-oxidase domain.he chromo domain ().nd the JAB1/PAD1 domain.
Mitochondrial P450-containing systems comprise 3 components.n FAD-containing flavoprotein NADPH:adrenodoxin reductase (AR); an iron-sulphur protein.drenodoxin; and P450 . The direction of electron flow is NADPH to AR to adrenodoxin to P450. FAD can be reduced by 2 electrons from NADPH.hich are transferred one at a time to adrenodoxin. one-electron carrier. Both AR and adrenodoxin are soluble proteins located on the matrix side of the inner mitochondrial membrane. Despite functional parallels.R shows no global similarity either to flavoprotein pyridine nucleotide cytochrome reductases (FPNCR) or to FAD-dependent pyridine nucleotide reductases (FADPNR) . However.LAST searches reveal local similarity of the N-terminal region of AR to glutamate synthase and NADH peroxidase.specially in the nucleotide-binding regions.uggesting that AR and FADPNR may be distantly related.
  IPR000759:Adrenodoxin reductase
SequencesProtein: LSD1_HUMAN (852 aa)
mRNA: BC040194 NM_015013
Local Annotation
Synapse Ontology
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentK00540
  Level 3 annotation:
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 166 residues, 23218532-23219027Exon2: 57 residues, 23229548-23229714Exon3: 46 residues, 23249466-23249600Exon4: 28 residues, 23252840-23252919Exon5: 33 residues, 23254148-23254241Exon6: 37 residues, 23255011-23255118Exon7: 29 residues, 23256563-23256645Exon8: 33 residues, 23258152-23258247Exon9: 49 residues, 23267618-23267761Exon10: 32 residues, 23268140-23268231Exon11: 47 residues, 23270304-23270439Exon12: 26 residues, 23271203-23271277Exon13: 39 residues, 23272371-23272483Exon14: 46 residues, 23276307-23276440Exon15: 64 residues, 23278069-23278257Exon16: 40 residues, 23278632-23278747Exon17: 44 residues, 23280525-23280653Exon18: 51 residues, 23281299-23281446Exon19: 173 residues, 23282258-23282771Exon20: 2 residues, -Jump to LSD1_HUMANExon1: 151 residues, 23218575-23219027Exon2: 57 residues, 23229548-23229714Exon3: 22 residues, 23243506-23243566Exon4: 46 residues, 23249466-23249600Exon5: 28 residues, 23252840-23252919Exon6: 33 residues, 23254148-23254241Exon7: 37 residues, 23255011-23255118Exon8: 29 residues, 23256563-23256645Exon9: 33 residues, 23258152-23258247Exon10: 6 residues, 23265139-23265151Exon11: 49 residues, 23267618-23267761Exon12: 32 residues, 23268140-23268231Exon13: 47 residues, 23270304-23270439Exon14: 26 residues, 23271203-23271277Exon15: 39 residues, 23272371-23272483Exon16: 46 residues, 23276307-23276440Exon17: 64 residues, 23278069-23278257Exon18: 40 residues, 23278632-23278747Exon19: 44 residues, 23280525-23280653Exon20: 51 residues, 23281299-23281446Exon21: 172 residues, 23282258-23282768Exon22: 2 residues, -Jump to LSD1_HUMAN  
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Loci Cluster (Details)Loci: 3779 23390975-23393809 ~-3K 651(HTR1D)(-)Loci: 3780 23757042-23758872 ~-2K 667(ID3)(-)Loci: 3781 24000954-24024536 ~-24K 680(HMGCL)(-)Loci: 3782 24073047-24112404 ~-39K 686(CNR2)(-)Loci: 3783 24168159-24179408 ~-11K 691(FUSIP1)(-)Loci: 2490 23218532-23282771 ~-64K 646(AOF2)(+)Link out to UCSC