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0ZFYV9_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZFYVE9
DescriptionZinc finger fyve domain-containing protein 9 (mothers against decapentaplegic homolog interacting protein) (madh-interacting protein) (smad anchor for receptor activation) (receptor activation anchor) (hsara) (novel serine protease) (nsp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (NAS)
0005769 early endosome (NAS)
0005515 protein binding (IPI)
0008236 serine-type peptidase activity (NAS)
0006897 endocytosis (NAS)
0007183 SMAD protein heteromerization (TAS)
0007184 SMAD protein nuclear translocation (TAS)
0007181 transforming growth factor beta receptor co... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The FYVE zinc finger is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. The FYVE finger has been shown to bind two Zn2+ ions . The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG.here + represents a charged residue and X any residue.
  IPR000306:Zinc finger, FYVE-type
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
IPR000306:FYVE 
Evalue:-25.6382721639824 
Location:691-759
SequencesProtein: ZFYV9_HUMAN (1425 aa)
mRNA: AF104304 NM_004799
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK04679
  Level 3 annotation:
    MAD, mothers against decapentaplegic interacting protein
  Level 2 annotation:
    TGF-beta signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 11 residues, 52380633-52380663Exon2: 37 residues, 52454628-52454734Exon3: 37 residues, 52471430-52471536Exon4: 704 residues, 52475747-52477855Exon5: 35 residues, 52502032-52502132Exon6: 61 residues, 52504914-52505091Exon7: 58 residues, 52506722-52506892Exon8: 42 residues, 52512723-52512844Exon9: 43 residues, 52516751-52516874Exon10: 54 residues, 52519920-52520076Exon11: 77 residues, 52531712-52531937Exon12: 29 residues, 52534154-52534237Exon13: 37 residues, 52542080-52542185Exon14: 52 residues, 52571027-52571178Exon15: 29 residues, 52572947-52573028Exon16: 56 residues, 52576031-52576194Exon17: 37 residues, 52578385-52578491Exon18: 61 residues, 52583027-52583204Exon19: 210 residues, 52584319-52584945Exon20: 2 residues, -Jump to ZFYV9_HUMANExon1: 32 residues, 52454639-52454734Exon2: 37 residues, 52471430-52471536Exon3: 704 residues, 52475747-52477855Exon4: 35 residues, 52502032-52502132Exon5: 61 residues, 52504914-52505091Exon6: 58 residues, 52506722-52506892Exon7: 42 residues, 52512723-52512844Exon8: 43 residues, 52516751-52516874Exon9: 54 residues, 52519920-52520076Exon10: 77 residues, 52531712-52531937Exon11: 29 residues, 52534154-52534237Exon12: 37 residues, 52542080-52542185Exon13: 52 residues, 52571027-52571178Exon14: 29 residues, 52572947-52573028Exon15: 56 residues, 52576031-52576194Exon16: 37 residues, 52578385-52578491Exon17: 61 residues, 52583027-52583204Exon18: 193 residues, 52584319-52584893Exon19: 2 residues, -Jump to ZFYV9_HUMAN  
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Loci Cluster (Details)Loci: 2516 52380633-52584945 ~-204K 1477(ZFYVE9)(+)Loci: 2517 52642887-52655284 ~-12K 1487(+)Loci: 3803 52157424-52228936 ~-72K 1473(RAB3B)(-)Link out to UCSC