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0PARD3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePARD3
DescriptionPartitioning-defective 3 homolog (pard-3) (par-3) (atypical pkc isotype-specific interacting protein) (asip) (ctcl tumor antigen se2- 5) (par3-alpha).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005923 tight junction (IDA)
0005515 protein binding (ISS)
0008356 asymmetric cell division (TAS)
0007409 axonogenesis (TAS)
0007163 establishment and/or maintenance of cell po... (TAS)
0006461 protein complex assembly (TAS)
0007205 protein kinase C activation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
IPR001478:PDZ 
Evalue:-20.6989707946777 
Location:461-545IPR001478:PDZ 
Evalue:-15.8538722991943 
Location:590-681IPR001478:PDZ 
Evalue:-5.08618614761628 
Location:282-361
SequencesProtein: PARD3_HUMAN (1356 aa)
mRNA: AF196185 AX765704
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04237
  Level 3 annotation:
    par-3 partitioning defective 3 homolog
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
    Adherens junction
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 668 residues, 34438494-34440496Exon2: 44 residues, 34448546-34448674Exon3: 42 residues, 34460396-34460517Exon4: 83 residues, 34598590-34598833Exon5: 39 residues, 34613068-34613179Exon6: 79 residues, 34646040-34646272Exon7: 78 residues, 34660050-34660278Exon8: 17 residues, 34665132-34665177Exon9: 52 residues, 34666208-34666360Exon10: 65 residues, 34670560-34670750Exon11: 55 residues, 34676889-34677049Exon12: 59 residues, 34688080-34688251Exon13: 65 residues, 34689004-34689193Exon14: 15 residues, 34701431-34701470Exon15: 45 residues, 34703807-34703936Exon16: 48 residues, 34706900-34707040Exon17: 129 residues, 34711473-34711856Exon18: 44 residues, 34713062-34713188Exon19: 30 residues, 34728263-34728347Exon20: 32 residues, 34730759-34730851Exon21: 46 residues, 34779250-34779382Exon22: 61 residues, 34799018-34799197Exon23: 62 residues, 34845912-34846093Exon24: 36 residues, 35025251-35025353Exon25: 42 residues, 35143809-35143929Exon26: 2 residues, -Jump to PARD3_HUMANExon1: 668 residues, 34438494-34440496Exon2: 44 residues, 34448546-34448674Exon3: 42 residues, 34460396-34460517Exon4: 83 residues, 34598590-34598833Exon5: 39 residues, 34613068-34613179Exon6: 79 residues, 34646040-34646272Exon7: 78 residues, 34660050-34660278Exon8: 17 residues, 34665132-34665177Exon9: 52 residues, 34666208-34666360Exon10: 65 residues, 34670560-34670750Exon11: 52 residues, 34676898-34677049Exon12: 59 residues, 34688080-34688251Exon13: 65 residues, 34689004-34689193Exon14: 15 residues, 34701431-34701470Exon15: 45 residues, 34703807-34703936Exon16: 48 residues, 34706900-34707040Exon17: 129 residues, 34711473-34711856Exon18: 44 residues, 34713062-34713188Exon19: 30 residues, 34728263-34728347Exon20: 32 residues, 34730759-34730851Exon21: 46 residues, 34779250-34779382Exon22: 61 residues, 34799018-34799197Exon23: 62 residues, 34845912-34846093Exon24: 36 residues, 35025251-35025353Exon25: 138 residues, 35143809-35144217Exon26: 2 residues, -Jump to PARD3_HUMAN  
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