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0NRIF3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameITGB3BP
DescriptionNuclear receptor-interacting factor 3 (integrin beta-3 binding protein) (beta3-endonexin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005624 membrane fraction (TAS)
0005634 nucleus (TAS)
0008022 protein C-terminus binding (TAS)
0004871 signal transducer activity (TAS)
0007155 cell adhesion (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of mammalian nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a coregulator that possesses both transactivation and transrepression domains and/or functions. Collectively.he NRIF3 family of coregulators may play dual roles in mediating both positive and negative regulatory effects on gene expression .
  IPR009601:Nuclear receptor co-activator NRIF3
IPR009601:NRIF3 
Evalue:-108.013229370117 
Location:41-170
SequencesProtein: NRIF3_HUMAN (177 aa)
mRNA: NM_014288 U37139
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 105 residues, 63679049-63679362Exon2: 19 residues, 63685064-63685115Exon3: 21 residues, 63692176-63692233Exon4: 33 residues, 63692638-63692732Exon5: 28 residues, 63693148-63693227Exon6: 25 residues, 63717022-63717092Exon7: 47 residues, 63728341-63728477Exon8: 16 residues, 63746786-63746829Exon9: 14 residues, 63761387-63761423Exon10: 2 residues, -Jump to NRIF3_HUMANExon1: 105 residues, 63679049-63679362Exon2: 19 residues, 63685064-63685115Exon3: 18 residues, 63685823-63685873Exon4: 21 residues, 63692176-63692233Exon5: 33 residues, 63692638-63692732Exon6: 28 residues, 63693148-63693227Exon7: 25 residues, 63717022-63717092Exon8: 47 residues, 63728341-63728477Exon9: 16 residues, 63746786-63746829Exon10: 31 residues, 63761387-63761474Exon11: 2 residues, -Jump to NRIF3_HUMAN  
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