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0ELTD1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameELTD1
DescriptionEgf, latrophilin and seven transmembrane domain containing protein 1 precursor (egf-tm7-latrophilin-related protein) (etl protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.
  IPR000832:GPCR, family 2, secretin-like
This domain has been termed the GPS domain (for GPCR proteolytic site).ecause it contains a cleavage site in latrophilin . However this region in latrophilin is found in many otherwise unrelated cell surface receptors . There is no evidence currently that this domain provides a cleavage site in any of the other receptors. However the peptide bond that is cleaved in latrophilin is between Leu and Thr residues that are conserved in some of the other receptors GPS domains are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.
  IPR000203:GPS
A sequence of about forty amino-acid residues found in epidermal growth factor (EGF) has been shown .o be present in a large number of membrane-bound and extracellular.ostly animal.roteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the N-terminus of some EGF-like domains . Calcium-binding may be crucial for numerous protein-protein interactions.For human coagulation factor IX it has been shown that the calcium-ligands form a pentagonal bipyramid. The first.hird and fourth conserved negatively charged or polar residues are side chain ligands. The latter is possibly hydroxylated (see aspartic acid and asparagine hydroxylation site) . A conserved aromatic residue.s well as the second conserved negative residue.re thought to be involved in stabilizing the calcium-binding site.As in non-calcium binding EGF-like domains.here are six conserved cysteines and the structure of both types is very similar as calcium-binding induces only strictly local structural changes .
  IPR001881:EGF-like calcium-binding
A sequence of about forty amino-acid residues found in epidermal growth factor (EGF) has been shown .o be present in a large number of membrane-bound and extracellular.ostly animal.roteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the N-terminus of some EGF-like domains . Calcium-binding may be crucial for numerous protein-protein interactions.For human coagulation factor IX it has been shown that the calcium-ligands form a pentagonal bipyramid. The first.hird and fourth conserved negatively charged or polar residues are side chain ligands. The latter is possibly hydroxylated (see aspartic acid and asparagine hydroxylation site) . A conserved aromatic residue.s well as the second conserved negative residue.re thought to be involved in stabilizing the calcium-binding site.As in non-calcium binding EGF-like domains.here are six conserved cysteines and the structure of both types is very similar as calcium-binding induces only strictly local structural changes .
  IPR013091:EGF calcium-binding
Epidermal growth factors and transforming growth factors belong to a general class of proteins that share a repeat pattern involving a number of conserved Cys residues. Growth factors are involved in cell recognition and division . The repeating pattern.specially of cysteines (the so-called EGF repeat).s thought to be important to the 3D structure of the proteins.nd hence its recognition by receptors and other molecules. The type 1 EGF signature includes six conserved cysteines believed to be involved in disulphide bond formation. The EGF motif is found frequently in nature.articularly in extracellular proteins.
  IPR006210:EGF
IPR000832:7tm_2 
Evalue:-73.5686340332031 
Location:424-671IPR000203:GPS 
Evalue:-20.7447280883789 
Location:366-418IPR001881:EGF_CA 
Evalue:-5.92081875395237 
Location:58-108IPR000742:EGF_3 
Evalue:0 
Location:18-57IPR002048:EF_HAND_1 
Evalue:0 
Location:153-165
SequencesProtein: ELTD1_HUMAN (690 aa)
mRNA: No corresponding mRNA found
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04595
  Level 3 annotation:
    latrophilin and seven transmembrane domain containing 1
  Level 2 annotation:
    G-protein coupled receptors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 205 residues, 79128876-79129489Exon2: 58 residues, 79129796-79129965Exon3: 32 residues, 79131370-79131462Exon4: 24 residues, 79155906-79155973Exon5: 75 residues, 79156102-79156323Exon6: 70 residues, 79158455-79158659Exon7: 60 residues, 79159885-79160059Exon8: 70 residues, 79165158-79165364Exon9: 41 residues, 79174567-79174684Exon10: 63 residues, 79176079-79176263Exon11: 62 residues, 79176372-79176552Exon12: 25 residues, 79177460-79177531Exon13: 53 residues, 79184546-79184699Exon14: 52 residues, 79243342-79243492Exon15: 16 residues, 79244905-79244949Exon16: 2 residues, -Jump to ELTD1_HUMANExon1: 205 residues, 79128876-79129489Exon2: 58 residues, 79129796-79129965Exon3: 32 residues, 79131370-79131462Exon4: 24 residues, 79155906-79155973Exon5: 75 residues, 79156102-79156323Exon6: 70 residues, 79158455-79158659Exon7: 60 residues, 79159885-79160059Exon8: 70 residues, 79165158-79165364Exon9: 41 residues, 79174567-79174684Exon10: 63 residues, 79176079-79176263Exon11: 62 residues, 79176372-79176552Exon12: 25 residues, 79177460-79177531Exon13: 53 residues, 79184546-79184699Exon14: 52 residues, 79243342-79243492Exon15: 16 residues, 79244905-79244949Exon16: 2 residues, -Jump to ELTD1_HUMAN  
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