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0ZW10_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZW10
DescriptionCentromere/kinetochore protein zw10 homolog.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000776 kinetochore (TAS)
0005828 kinetochore microtubule (IDA)
0005634 nucleus (NAS)
0000922 spindle pole (IDA)
0019237 centromeric DNA binding (TAS)
0005515 protein binding (IPI)
0007126 meiosis (TAS)
0007093 mitotic checkpoint (IDA)
0000070 mitotic sister chromatid segregation (TAS)
0006461 protein complex assembly (NAS)
0007096 regulation of exit from mitosis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis . These proteins bind to the centromere/kinetochore .
  IPR009361:Centromerekinetochore Zw10
IPR009361:Zw10 
Evalue:-1e+125 
Location:8-620
SequencesProtein: ZW10_HUMAN (778 aa)
mRNA: NM_004724
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 209 residues, 113109120-113109746Exon2: 69 residues, 113112551-113112754Exon3: 46 residues, 113113503-113113635Exon4: 45 residues, 113114195-113114326Exon5: 58 residues, 113115144-113115314Exon6: 26 residues, 113117625-113117697Exon7: 81 residues, 113119733-113119972Exon8: 63 residues, 113123462-113123645Exon9: 56 residues, 113124188-113124352Exon10: 66 residues, 113133593-113133785Exon11: 53 residues, 113134485-113134638Exon12: 55 residues, 113136140-113136300Exon13: 28 residues, 113136444-113136522Exon14: 36 residues, 113136748-113136850Exon15: 47 residues, 113144764-113144899Exon16: 49 residues, 113149493-113149635Exon17: 2 residues, -Jump to ZW10_HUMAN  
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Loci Cluster (Details)Loci: 3992 113063482-113082305 ~-19K 7767(TMPRSS5)(-)Loci: 3993 113109120-113149635 ~-41K 7769(ZW10)(-)Loci: 2706 113280798-113322492 ~-42K 7774(+)Loci: 2707 113351119-113366242 ~-15K 7775(HTR3A)(+)Loci: 2708 113435640-113626604 ~-191K 7782(ZBTB16)(+)Loci: 3991 112785527-112851091 ~-66K 7762(DRD2)(-)Link out to UCSC