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0ZNF25_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZNF25
DescriptionZinc finger protein 25 (zinc finger protein kox19).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Krueppel-associated box (KRAB) is a domain of around 75 amino acids that is found in the N-terminal part of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs) . It is enriched in charged amino acids and can be divided into subregions A and B.hich are predicted to fold into two amphipathic alpha-helices. The KRAB A and B boxes can be separated by variable spacer segments and many KRAB proteins contain only the A box .The functions currently known for members of the KRAB-containing protein family include transcriptional repression of RNA polymerase I.I.nd III promoters.inding and splicing of RNA.nd control of nucleolus function. The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. A sequence of 45 amino acids in the KRAB A subdomain has been shown to be necessary and sufficient for transcriptional repression. The B box does not repress by itself but does potentiate the repression exerted by the KRAB A subdomain . Gene silencing requires the binding of the KRAB domain to the RING-B box-coiled coil (RBCC) domain of the KAP-1/TIF1-beta corepressor. As KAP-1 binds to the heterochromatin proteins HP1.t has been proposed that the KRAB-ZFP-bound target gene could be silenced following recruitment to heterochromatin .KRAB-ZFPs probably constitute the single largest class of transcription factors within the human genome . Although the function of KRAB-ZFPs is largely unknown.hey appear to play important roles during cell differentiation and development. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B.
  IPR001909:KRAB box
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007086:Zinc finger, C2H2-subtype
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR001909:KRAB 
Evalue:-34.8239087409443 
Location:8-68IPR007087:zf-C2H2 
Evalue:-7.88605642318726 
Location:258-280IPR007087:zf-C2H2 
Evalue:-7.22914791107178 
Location:286-308IPR007087:zf-C2H2 
Evalue:-7.20065927505493 
Location:426-448IPR007087:zf-C2H2 
Evalue:-6.79587984085083 
Location:398-420IPR007087:zf-C2H2 
Evalue:-6.69896984100342 
Location:342-364IPR007087:zf-C2H2 
Evalue:-6.69896984100342 
Location:146-168IPR007087:zf-C2H2 
Evalue:-6.46852111816406 
Location:370-392IPR007087:zf-C2H2 
Evalue:-5.82390880584717 
Location:314-336IPR007087:zf-C2H2 
Evalue:-5.38721609115601 
Location:174-196IPR007087:zf-C2H2 
Evalue:-5.25181198120117 
Location:202-224IPR007087:zf-C2H2 
Evalue:-5.24412536621094 
Location:230-252IPR007087:zf-C2H2 
Evalue:-4 
Location:118-140
SequencesProtein: ZNF25_HUMAN (456 aa)
mRNA: NM_145011
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1110 residues, 38278800-38282129Exon2: 23 residues, 38282628-38282692Exon3: 34 residues, 38285953-38286049Exon4: 44 residues, 38286353-38286480Exon5: 35 residues, 38300641-38300741Exon6: 8 residues, 38305439-38305459Exon7: 2 residues, -Jump to ZNF25_HUMAN  
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