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0ZN638_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZNF638
DescriptionZinc finger protein 638 (nuclear protein 220) (zinc-finger matrin-like protein) (cutaneous t-cell lymphoma associated antigen se33-1) (ctcl tumor antigen se33-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005654 nucleoplasm (TAS)
0003690 double-stranded DNA binding (TAS)
0003723 RNA binding (TAS)
0008380 RNA splicing (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.U1-type zinc fingers are a family of C2H2-type zinc fingers present in matrin.1 small nuclear ribonucleoprotein C and other RNA-binding proteins.
  IPR003604:Zinc finger, U1-type
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR003604:ZnF_U1 
Evalue:-7.22914798835785 
Location:1925-1959IPR000504:RRM 
Evalue:-5.63827216398241 
Location:677-747IPR012677:Nucl_bd_a/b_plat 
Evalue:0 
Location:1006-1102IPR012677:Nucl_bd_a/b_plat 
Evalue:0 
Location:902-977IPR007087:ZINC_FINGER_C2H2_1 
Evalue:0 
Location:428-450
SequencesProtein: ZN638_HUMAN (1978 aa)
mRNA: BC083513 NM_014497
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 40 residues, 71412396-71412513Exon2: 508 residues, 71429390-71430909Exon3: 22 residues, 71436356-71436418Exon4: 15 residues, 71443790-71443829Exon5: 101 residues, 71444591-71444890Exon6: 94 residues, 71446066-71446344Exon7: 51 residues, 71449019-71449166Exon8: 43 residues, 71450520-71450643Exon9: 21 residues, 71460859-71460918Exon10: 19 residues, 71461150-71461203Exon11: 19 residues, 71476778-71476829Exon12: 26 residues, 71479338-71479410Exon13: 31 residues, 71480196-71480283Exon14: 25 residues, 71480749-71480818Exon15: 15 residues, 71481115-71481156Exon16: 46 residues, 71482593-71482725Exon17: 45 residues, 71484507-71484636Exon18: 16 residues, 71486238-71486280Exon19: 47 residues, 71486765-71486900Exon20: 44 residues, 71488759-71488885Exon21: 14 residues, 71499239-71499277Exon22: 410 residues, 71503451-71504676Exon23: 24 residues, 71505287-71505353Exon24: 320 residues, 71507097-71508052Exon25: 37 residues, 71509184-71509289Exon26: 36 residues, 71511964-71512066Exon27: 41 residues, 71513802-71513921Exon28: 107 residues, 71515379-71515695Exon29: 2 residues, -Jump to ZN638_HUMANExon1: 27 residues, 71412433-71412513Exon2: 508 residues, 71429390-71430909Exon3: 22 residues, 71436356-71436418Exon4: 15 residues, 71443790-71443829Exon5: 101 residues, 71444591-71444890Exon6: 94 residues, 71446066-71446344Exon7: 51 residues, 71449019-71449166Exon8: 43 residues, 71450520-71450643Exon9: 21 residues, 71460859-71460918Exon10: 19 residues, 71461150-71461203Exon11: 19 residues, 71476778-71476829Exon12: 26 residues, 71479338-71479410Exon13: 31 residues, 71480196-71480283Exon14: 25 residues, 71480749-71480818Exon15: 15 residues, 71481115-71481156Exon16: 46 residues, 71482593-71482725Exon17: 45 residues, 71484507-71484636Exon18: 16 residues, 71486238-71486280Exon19: 47 residues, 71486765-71486900Exon20: 44 residues, 71488759-71488885Exon21: 14 residues, 71499239-71499277Exon22: 410 residues, 71503451-71504676Exon23: 24 residues, 71505287-71505353Exon24: 320 residues, 71507097-71508052Exon25: 37 residues, 71509184-71509289Exon26: 36 residues, 71511964-71512066Exon27: 20 residues, 71513865-71513921Exon28: 107 residues, 71515379-71515695Exon29: 2 residues, -Jump to ZN638_HUMAN  
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Loci Cluster (Details)Loci: 3169 71412396-71515695 ~-103K 20632(ZNF638)(+)Loci: 3168 71016505-71046068 ~-30K 20619(ATP6V1B1)(+)Link out to UCSC