SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0ZN263_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZNF263
DescriptionZinc finger protein 263 (zinc finger protein fpm315).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003700 transcription factor activity (TAS)
0006355 regulation of transcription, DNA-dependent (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/572827327.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of C2H2-zinc finger proteins contain a highly conserved N-terminal motif termed the SCAN domain. The SCAN domain may play an important role in the assembly and function of this newly defined subclass of transcriptional regulators .
  IPR003309:Transcriptional regulator SCAN
The Krueppel-associated box (KRAB) is a domain of around 75 amino acids that is found in the N-terminal part of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs) . It is enriched in charged amino acids and can be divided into subregions A and B.hich are predicted to fold into two amphipathic alpha-helices. The KRAB A and B boxes can be separated by variable spacer segments and many KRAB proteins contain only the A box .The functions currently known for members of the KRAB-containing protein family include transcriptional repression of RNA polymerase I.I.nd III promoters.inding and splicing of RNA.nd control of nucleolus function. The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. A sequence of 45 amino acids in the KRAB A subdomain has been shown to be necessary and sufficient for transcriptional repression. The B box does not repress by itself but does potentiate the repression exerted by the KRAB A subdomain . Gene silencing requires the binding of the KRAB domain to the RING-B box-coiled coil (RBCC) domain of the KAP-1/TIF1-beta corepressor. As KAP-1 binds to the heterochromatin proteins HP1.t has been proposed that the KRAB-ZFP-bound target gene could be silenced following recruitment to heterochromatin .KRAB-ZFPs probably constitute the single largest class of transcription factors within the human genome . Although the function of KRAB-ZFPs is largely unknown.hey appear to play important roles during cell differentiation and development. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B.
  IPR001909:KRAB box
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007086:Zinc finger, C2H2-subtype
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
Members of this family display a core structure consisting of a closed bundle of four helices in a left-handed twist.ith two crossover connections. Family members include long-chain cytokines.uch as leukaemia inhibitory factor (LIF) .he growth hormone somatotropin .nterleukin-6 and leptin ; short-chain cytokines.uch as erythropoietin .tem cell factor (SCF) .acrophage colony-stimulating factor (M-CSF) and interleukin-2.3.4.5 and -13; and interferons/interleukin-10.Please be aware that some of the protein hits may be false positives.
  IPR009079:Four-helical cytokine
IPR003309:LER 
Evalue:-73.1366771398795 
Location:37-149IPR001909:KRAB 
Evalue:-17.6197887582884 
Location:217-278IPR007087:zf-C2H2 
Evalue:-8.35654735565185 
Location:518-540IPR007087:zf-C2H2 
Evalue:-7.69896984100342 
Location:490-512IPR007087:zf-C2H2 
Evalue:-7.14874172210693 
Location:603-625IPR007087:zf-C2H2 
Evalue:-7.02687215805054 
Location:659-681IPR007087:zf-C2H2 
Evalue:-6.619788646698 
Location:378-400IPR007087:zf-C2H2 
Evalue:-5.69896984100342 
Location:575-597IPR007087:zf-C2H2 
Evalue:-5.60205984115601 
Location:434-456IPR007087:zf-C2H2 
Evalue:-5.17392539978027 
Location:462-484IPR007087:zf-C2H2 
Evalue:-4.92081880569458 
Location:631-653
SequencesProtein: ZN263_HUMAN (683 aa)
mRNA: NM_005741
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 240 residues, 3273487-3274206Exon2: 62 residues, 3275059-3275240Exon3: 26 residues, 3275681-3275755Exon4: 44 residues, 3276023-3276150Exon5: 41 residues, 3278454-3278571Exon6: 689 residues, 3279393-3281456Exon7: 2 residues, -Jump to ZN263_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2919 3036682-3050723 ~-14K 13385(MMP25)(+)Loci: 4203 3232028-3246628 ~-15K 13403(MEFV)(-)Loci: 2920 3273487-3281456 ~-8K 13405(ZNF263)(+)Loci: 4204 3571183-3601586 ~-30K 13423(BTBD12)(-)Loci: 4205 3648039-3707514 ~-59K 13426(TRAP1)(-)Loci: 4206 3717719-3870723 ~-153K 13429(CREBBP)(-)Loci: 4202 2962794-2970475 ~-8K 13372(PKMYT1)(-)Link out to UCSC