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0ZN219_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionZinc finger protein 219.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0003700 transcription factor activity (TAS)
0006351 transcription, DNA-dependent (TAS)

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Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Histamine is distributed within mast cells in all peripheral tissues and is a well-characterised mediator of inflammation and allergy . It also regulates release of gastric acid from parietal cells in the gastric mucosa. H3 receptors function as presynaptic autoreceptors on histamine-containing neurones. They are expressed abundantly in the central nervous system.ith highest levels found in the thalamus.audate nucleus and cortex. High levels of expression are also found in the hypothalamus.ippocampus and olfactory tubercle. In the periphery.ow levels of H3 have been detected in the human small intestine.estis and prostate but not in a number of other tissues tested.ncluding the heart.ung and spleen . Binding of histamine to H3 receptors results in inhibition of forskolin-stimulated cAMP accumulation.uggesting coupling to a G-protein of the Gi class .
  IPR003980:Histamine H3 receptor
InterPro domains unassigned to SynO:
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
SequencesProtein: ZN219_HUMAN (722 aa)
mRNA: NM_016423
Local Annotation
Synapse Ontology
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 355 residues, 20628075-20629139Exon2: 46 residues, 20629409-20629541Exon3: 477 residues, 20629863-20631289Exon4: 31 residues, 20631584-20631673Exon5: 111 residues, 20636310-20636639Exon6: 2 residues, -Jump to ZN219_HUMAN  
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Loci Cluster (Details)Loci: 4114 20997027-21014961 ~-18K 10801(RAB2B)(-)Loci: 4113 20628075-20636639 ~-9K 10786(ZNF219)(-)Link out to UCSC