SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0ZN142_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZNF142
DescriptionZinc finger protein 142 (ha4654).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003700 transcription factor activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
Members of this family display a core structure consisting of a closed bundle of four helices in a left-handed twist.ith two crossover connections. Family members include long-chain cytokines.uch as leukaemia inhibitory factor (LIF) .he growth hormone somatotropin .nterleukin-6 and leptin ; short-chain cytokines.uch as erythropoietin .tem cell factor (SCF) .acrophage colony-stimulating factor (M-CSF) and interleukin-2.3.4.5 and -13; and interferons/interleukin-10.Please be aware that some of the protein hits may be false positives.
  IPR009079:Four-helical cytokine
IPR007087:zf-C2H2 
Evalue:-5.95860719680786 
Location:1565-1587IPR007087:zf-C2H2 
Evalue:-4.38721609115601 
Location:1536-1559IPR007087:zf-C2H2 
Evalue:-4.36653137207031 
Location:457-479IPR007087:zf-C2H2 
Evalue:-4.01322841644287 
Location:1593-1615IPR007087:zf-C2H2 
Evalue:-3.92081880569458 
Location:253-275IPR007087:zf-C2H2 
Evalue:-3.03621220588684 
Location:1480-1502IPR007087:zf-C2H2 
Evalue:-3 
Location:1200-1222IPR007087:ZnF_C2H2 
Evalue:-2.92081875395237 
Location:1508-1530IPR007087:zf-C2H2 
Evalue:-2.76955103874207 
Location:401-423IPR007087:zf-C2H2 
Evalue:-2.67778062820435 
Location:429-451IPR007087:zf-C2H2 
Evalue:-2.46852111816406 
Location:512-535IPR007087:zf-C2H2 
Evalue:-2.29242992401123 
Location:1286-1309IPR007087:ZnF_C2H2 
Evalue:-2.23657200643706 
Location:219-242IPR007087:zf-C2H2 
Evalue:-2.18045616149902 
Location:163-185IPR007087:zf-C2H2 
Evalue:-2.09690999984741 
Location:866-889IPR007087:zf-C2H2 
Evalue:-2.0915150642395 
Location:1228-1251IPR007087:zf-C2H2 
Evalue:-1.74472749233246 
Location:836-859IPR007087:ZnF_C2H2 
Evalue:-1.63827216398241 
Location:286-311IPR007087:ZnF_C2H2 
Evalue:-1.29242982390206 
Location:1354-1377IPR007087:zf-C2H2 
Evalue:-1.25181198120117 
Location:1452-1474IPR007087:ZnF_C2H2 
Evalue:-1.02227639471115 
Location:485-507IPR007087:ZnF_C2H2 
Evalue:-1 
Location:1135-1158IPR007087:ZnF_C2H2 
Evalue:-0.795880017344075 
Location:1621-1643IPR007087:ZnF_C2H2 
Evalue:-0.721246399047171 
Location:1380-1403IPR007087:ZnF_C2H2 
Evalue:-0.657577319177794 
Location:372-395IPR007087:ZnF_C2H2 
Evalue:-0.292429823902064 
Location:1328-1351IPR007087:ZnF_C2H2 
Evalue:-0.2518119729938 
Location:1171-1194IPR007087:ZnF_C2H2 
Evalue:-0.154901959985743 
Location:343-366IPR007087:ZnF_C2H2 
Evalue:-0.0969100130080564 
Location:1424-1446IPR007087:ZINC_FINGER_C2H2_2 
Evalue:0 
Location:191-218IPR007087:ZINC_FINGER_C2H2_1 
Evalue:0 
Location:318-340IPR003006:IG_MHC 
Evalue:0 
Location:0-0IPR007087:ZnF_C2H2 
Evalue:0.602059991327962 
Location:573-596IPR007087:ZnF_C2H2 
Evalue:0.826074802700826 
Location:1257-1280IPR007087:ZnF_C2H2 
Evalue:0.845098040014257 
Location:544-567IPR007087:ZnF_C2H2 
Evalue:1.39794000867204 
Location:1104-1124IPR007087:ZnF_C2H2 
Evalue:2.25527250510331 
Location:1026-1046
SequencesProtein: ZN142_HUMAN (1687 aa)
mRNA: D87073 NM_005081
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 297 residues, 219210885-219211775Exon2: 37 residues, 219213630-219213736Exon3: 1014 residues, 219214994-219218031Exon4: 61 residues, 219219137-219219315Exon5: 277 residues, 219221601-219222426Exon6: 58 residues, 219223325-219223493Exon7: 42 residues, 219224667-219224789Exon8: 106 residues, 219229116-219229430Exon9: 60 residues, 219231667-219231843Exon10: 52 residues, 219231946-219232097Exon11: 90 residues, 219232335-219232599Exon12: 2 residues, -Jump to ZN142_HUMANExon1: 283 residues, 219210927-219211775Exon2: 37 residues, 219213630-219213736Exon3: 1014 residues, 219214994-219218031Exon4: 61 residues, 219219137-219219315Exon5: 277 residues, 219221601-219222426Exon6: 58 residues, 219223325-219223493Exon7: 106 residues, 219229116-219229430Exon8: 60 residues, 219231667-219231843Exon9: 20 residues, 219231946-219232002Exon10: 58 residues, 219232335-219232505Exon11: 2 residues, -Jump to ZN142_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3213 219232701-219236409 ~-4K 22084(BCS1L)(+)Loci: 3214 219354948-219388259 ~-33K 22089(CYP27A1)(+)Loci: 3215 219532641-219535120 ~-2K 22095(CDK5R2)(+)Loci: 4494 219782737-219791916 ~-9K 22116(ABCB6)(-)Loci: 3216 219991342-219999703 ~-8K 22140(DES)(+)Loci: 3217 220087295-220111732 ~-24K 22148(ACCN4)(+)Loci: 3218 220145197-220148671 ~-3K 22154(INHA)(+)Loci: 4493 219210885-219232599 ~-22K 22082(ZNF142)(-)Link out to UCSC