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0ZFYV1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZFYVE1
DescriptionZinc finger fyve domain-containing protein 1 (double fyve-containing protein 1) (tandem fyve fingers-1) (sr3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (IDA)
0005795 Golgi stack (IDA)
0048471 perinuclear region (IDA)
0005545 phosphatidylinositol binding (IDA)
0005547 phosphatidylinositol-3,4,5-triphosphate bin... (IDA)
0043325 phosphatidylinositol-3,4-bisphosphate binding (IDA)
0008270 zinc ion binding (NAS)
0016192 vesicle-mediated transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The FYVE zinc finger is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. The FYVE finger has been shown to bind two Zn2+ ions . The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG.here + represents a charged residue and X any residue.
  IPR000306:Zinc finger, FYVE-type
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
IPR000306:FYVE 
Evalue:-13.5376024246216 
Location:593-660IPR000306:FYVE 
Evalue:-13.4814863204956 
Location:710-776
SequencesProtein: ZFYV1_HUMAN (777 aa)
mRNA: NM_021260
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 555 residues, 72505912-72507575Exon2: 40 residues, 72510540-72510654Exon3: 62 residues, 72511239-72511420Exon4: 59 residues, 72512011-72512182Exon5: 41 residues, 72514387-72514505Exon6: 34 residues, 72514597-72514695Exon7: 38 residues, 72515321-72515430Exon8: 37 residues, 72518249-72518356Exon9: 73 residues, 72529603-72529818Exon10: 170 residues, 72534271-72534776Exon11: 307 residues, 72560486-72561403Exon12: 70 residues, 72563386-72563592Exon13: 2 residues, -Jump to ZFYV1_HUMAN  
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Loci Cluster (Details)Loci: 2852 72672931-72756862 ~-84K 11422(PSEN1)(+)Loci: 4139 72811670-72995039 ~-183K 11431(NUMB)(-)Loci: 4138 72505912-72563592 ~-58K 11418(ZFYVE1)(-)Link out to UCSC