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0ZFY16_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZFYVE16
DescriptionZinc finger fyve domain-containing protein 16 (endofin) (endosome- associated fyve domain protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005769 early endosome (IDA)
0005545 phosphatidylinositol binding (IDA)
0005515 protein binding (IPI)
0008565 protein transporter activity (IMP)
0016197 endosome transport (IMP)
0006622 protein-lysosome targeting (IMP)
0030100 regulation of endocytosis (TAS)
0007165 signal transduction (NAS)
0016050 vesicle organization and biogenesis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The FYVE zinc finger is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. The FYVE finger has been shown to bind two Zn2+ ions . The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG.here + represents a charged residue and X any residue.
  IPR000306:Zinc finger, FYVE-type
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
IPR000306:FYVE 
Evalue:-33.6777801513672 
Location:742-806
SequencesProtein: ZFY16_HUMAN (1539 aa)
mRNA: NM_014733
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
endosomal intermediate functions as a sorting station before be redirected into the recycling vesicle population.
sdb:0150 endosomal intermediate  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentK04679
  Level 3 annotation:
    MAD, mothers against decapentaplegic interacting protein
  Level 2 annotation:
    TGF-beta signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 31 residues, 79739638-79739728Exon2: 38 residues, 79765683-79765792Exon3: 752 residues, 79768330-79770582Exon4: 34 residues, 79771510-79771607Exon5: 56 residues, 79774697-79774859Exon6: 49 residues, 79776837-79776980Exon7: 128 residues, 79779600-79779979Exon8: 43 residues, 79781165-79781288Exon9: 54 residues, 79782005-79782161Exon10: 77 residues, 79783059-79783284Exon11: 29 residues, 79787266-79787349Exon12: 37 residues, 79788035-79788140Exon13: 51 residues, 79788519-79788667Exon14: 29 residues, 79790988-79791069Exon15: 56 residues, 79804335-79804498Exon16: 37 residues, 79805328-79805434Exon17: 58 residues, 79806237-79806405Exon18: 563 residues, 79808793-79810476Exon19: 2 residues, -Jump to ZFY16_HUMAN  
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