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0ZDH13_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZDHHC13
DescriptionZinc finger dhhc domain containing protein 13 (huntingtin-interacting protein 14 related protein) (hip14-related protein) (huntingtin- interacting protein hip3rp) (putative nf-kappa-b-activating protein 209) (putative mapk-activating protein pm03).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004871 signal transducer activity (IMP)
0043123 positive regulation of I-kappaB kinase/NF-k... (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is also known as NEW1 . The DHHC Zn-finger was first isolated in the Drosophila putative transcription factor DNZ1 . The function of this domain is unknown.ut it has been predicted to be involved in protein-protein or protein-DNA interactions .
  IPR001594:Zinc finger, DHHC-type
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
  IPR002110:Ankyrin
IPR001594:zf-DHHC 
Evalue:-19.5228786468506 
Location:418-481IPR002110:Ank 
Evalue:-8.03621196746826 
Location:216-248IPR002110:Ank 
Evalue:-7.67778062820435 
Location:115-147IPR002110:Ank 
Evalue:-5.36653137207031 
Location:148-180IPR002110:Ank 
Evalue:-2.48148608207703 
Location:81-113IPR002110:Ank 
Evalue:-2.42021632194519 
Location:181-214IPR002110:Ank 
Evalue:-0.46852108836174 
Location:249-269IPR002110:Ank 
Evalue:1.55630254745483 
Location:65-80
SequencesProtein: ZDH13_HUMAN (622 aa)
mRNA: BC036020 NM_019028
Local Annotation
Synapse Ontology
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 45 residues, 19095267-19095399Exon2: 50 residues, 19121100-19121246Exon3: 43 residues, 19124303-19124426Exon4: 28 residues, 19125718-19125796Exon5: 50 residues, 19127309-19127454Exon6: 23 residues, 19128849-19128914Exon7: 56 residues, 19130280-19130443Exon8: 44 residues, 19130681-19130807Exon9: 46 residues, 19133918-19134052Exon10: 35 residues, 19137062-19137163Exon11: 43 residues, 19141425-19141550Exon12: 23 residues, 19142423-19142486Exon13: 33 residues, 19143174-19143268Exon14: 30 residues, 19144424-19144508Exon15: 54 residues, 19148533-19148691Exon16: 34 residues, 19150845-19150943Exon17: 201 residues, 19153944-19154542Exon18: 2 residues, -Jump to ZDH13_HUMANExon1: 39 residues, 19095284-19095399Exon2: 50 residues, 19121100-19121246Exon3: 42 residues, 19124303-19124424Exon4: 28 residues, 19125716-19125796Exon5: 50 residues, 19127309-19127454Exon6: 23 residues, 19128849-19128914Exon7: 56 residues, 19130280-19130443Exon8: 44 residues, 19130681-19130807Exon9: 46 residues, 19133918-19134052Exon10: 35 residues, 19137062-19137163Exon11: 43 residues, 19141425-19141550Exon12: 23 residues, 19142423-19142486Exon13: 33 residues, 19143174-19143268Exon14: 30 residues, 19144424-19144508Exon15: 54 residues, 19148533-19148691Exon16: 34 residues, 19150845-19150943Exon17: 199 residues, 19153944-19154537Exon18: 2 residues, -Jump to ZDH13_HUMAN  
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