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0ZBT16_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZBTB16
DescriptionZinc finger and btb domain containing protein 16 (zinc finger protein plzf) (promyelocytic leukemia zinc finger protein) (zinc finger protein 145).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (TAS)
0003700 transcription factor activity (TAS)
0007498 mesoderm development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR013069:BTB/POZ
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR000210:BTB
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR013069:BTB 
Evalue:-29.8239078521729 
Location:24-126IPR007087:zf-C2H2 
Evalue:-5.69896984100342 
Location:518-540IPR007087:zf-C2H2 
Evalue:-5.56863641738892 
Location:574-596IPR007087:zf-C2H2 
Evalue:-4.92081880569458 
Location:546-568IPR007087:zf-C2H2 
Evalue:-4.26760625839233 
Location:461-483IPR007087:zf-C2H2 
Evalue:-3.25963735580444 
Location:630-652IPR007087:zf-C2H2 
Evalue:-2.58502674102783 
Location:602-624IPR007087:zf-C2H2 
Evalue:-1.95860731601715 
Location:432-454IPR007087:zf-C2H2 
Evalue:-1.82390868663788 
Location:490-512IPR007087:ZINC_FINGER_C2H2_2 
Evalue:0 
Location:404-431
SequencesProtein: ZBT16_HUMAN (673 aa)
mRNA: NM_006006
Local Annotation
Synapse Ontology
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 59 residues, 113435640-113435814Exon2: 454 residues, 113439142-113440500Exon3: 34 residues, 113532268-113532366Exon4: 31 residues, 113562883-113562970Exon5: 59 residues, 113618098-113618269Exon6: 58 residues, 113623129-113623297Exon7: 117 residues, 113626257-113626604Exon8: 2 residues, -Jump to ZBT16_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3992 113063482-113082305 ~-19K 7767(TMPRSS5)(-)Loci: 3993 113109120-113149635 ~-41K 7769(ZW10)(-)Loci: 2706 113280798-113322492 ~-42K 7774(+)Loci: 2707 113351119-113366242 ~-15K 7775(HTR3A)(+)Loci: 2708 113435640-113626604 ~-191K 7782(ZBTB16)(+)Loci: 3991 112785527-112851091 ~-66K 7762(DRD2)(-)Link out to UCSC