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0XRN2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameXRN2
Description5'-3' exoribonuclease 2 (ec 3.1.11.-) (dhm1-like protein) (dhp protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (ISS)
0004534 5'-3' exoribonuclease activity (TAS)
0004518 nuclease activity (TAS)
0005515 protein binding (IPI)
0016049 cell growth (ISS)
0006310 DNA recombination (ISS)
0006281 DNA repair (ISS)
0007017 microtubule-based process (ISS)
0006401 RNA catabolism (TAS)
0006396 RNA processing (TAS)
0007283 spermatogenesis (IEP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Signatures of this entry align residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear topossess 5-3 exonuclease activity EC:3.1.11.-. Thus.he aligned region may be necessary for 5-3 exonuclease function.
  IPR004859:Putative 5-3 exonuclease
The 18 residues CCHC zinc finger domain is mainly found in the Nucleocapsid protein of retrovirus. It is required for viral genome packaging and for early infection process . It is also found in eukaryotic proteins involved in RNA binding or single strand DNA binding.
  IPR001878:Zinc finger, CCHC-type
IPR004859:XRN_N 
Evalue:-193.958602905273 
Location:1-255IPR001878:ZF_CCHC 
Evalue:0 
Location:0-0IPR001878:ZnF_C2HC 
Evalue:0.414973347970818 
Location:262-278
SequencesProtein: XRN2_HUMAN (950 aa)
mRNA: NM_012255
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK01146
  Level 3 annotation:
    
  Level 2 annotation:
    Other replication
     recombination and repair proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 57 residues, 21231941-21232111Exon2: 44 residues, 21254916-21255044Exon3: 39 residues, 21255127-21255239Exon4: 39 residues, 21257196-21257308Exon5: 21 residues, 21259118-21259177Exon6: 32 residues, 21259253-21259343Exon7: 26 residues, 21260198-21260271Exon8: 19 residues, 21260405-21260456Exon9: 54 residues, 21260920-21261078Exon10: 27 residues, 21262181-21262256Exon11: 46 residues, 21262341-21262475Exon12: 21 residues, 21262574-21262632Exon13: 38 residues, 21262715-21262823Exon14: 17 residues, 21267681-21267726Exon15: 46 residues, 21269358-21269490Exon16: 41 residues, 21272727-21272846Exon17: 47 residues, 21275052-21275188Exon18: 38 residues, 21276783-21276891Exon19: 32 residues, 21276978-21277068Exon20: 26 residues, 21278026-21278099Exon21: 30 residues, 21283426-21283510Exon22: 34 residues, 21284717-21284815Exon23: 28 residues, 21285223-21285303Exon24: 21 residues, 21286373-21286430Exon25: 25 residues, 21294058-21294127Exon26: 46 residues, 21294210-21294342Exon27: 44 residues, 21297100-21297228Exon28: 23 residues, 21310631-21310695Exon29: 48 residues, 21315505-21315644Exon30: 186 residues, 21317910-21318463Exon31: 2 residues, -Jump to XRN2_HUMAN  
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