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0WNT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameWNT1
DescriptionWnt-1 proto-oncogene protein precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005102 receptor binding (NAS)
0030154 cell differentiation (TAS)
0001708 cell fate specification (TAS)
0016477 cell migration (TAS)
0007417 central nervous system development (TAS)
0007163 establishment and/or maintenance of cell po... (TAS)
0009653 morphogenesis (TAS)
0016055 Wnt receptor signaling pathway (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Wnt-1 (previously known as int-1) is a proto-oncogene induced by the integration of the mouse mammary tumor virus. It is thought to play a role in intercellular communication and seems to be a signalling molecule important in the development of the central nervous system (CNS). The sequence of wnt-1 is highly conserved in mammals.ish.nd amphibians. Wnt-1 is a member of a large family of related proteins that are all thought to be developmental regulators. These proteins are known as wnt-2 (also known as irp).nt-3 up to wnt-15. At least four members of this family are present in Drosophila. One of them.ingless (wg).s implicated in segmentation polarity. All these proteins share the following features characteristics of secretory proteins. signal peptide.everal potential N-glycosylation sites and 22 conserved cysteines that are probably involved in disulphide bonds. The Wnt proteins seem to adhere to the plasma membrane of the secreting cells and are therefore likely to signal over only few cell diameters.
  IPR005817:Wnt superfamily
Wnt proteins constitute a large family of secreted molecules that areinvolved in intercellular signalling during development. The name derivesfrom the first 2 members of the family to be discovered: int-1 (mouse) andwingless (Drosophila) . It is now recognised that Wnt signalling controlsmany cell fate decisions in a variety of different organisms.ncludingmammals . Wnt signalling has been implicated in tumorigenesis.arlymesodermal patterning of the embryo.orphogenesis of the brain and kidneys.egulation of mammary gland proliferation and Alzheimers disease .Wnt-mediated signalling is believed to proceed initially through binding tocell surface receptors of the frizzled family; the signal is subsequentlytransduced through several cytoplasmic components to B-catenin.hich entersthe nucleus and activates the transcription of several genes important indevelopment . More recently.owever.everal non-canonical Wntsignalling pathways have been elucidated that act independently ofB-catenin. Members of the Wnt gene family are defined by their sequencesimilarity to mouse Wnt-1 and Wingless in Drosophila. They encode proteinsof ~350-400 residues in length.ith orthologues identified in several.ostly vertebrate.pecies. Very little is known about the structure of Wnts as they are notoriously insoluble; in terms of primary structure.hefamily is characterised by a signal sequence and an almost invariant patternof 23-24 conserved cysteines . Fifteen major Wnt gene families have been identified in vertebrates.ith multiple subtypes within some classes.In humans.9 Wnt proteins have been identified that share 27% to 83% amino-acid sequence identity and a conserved pattern of 23 or 24 cysteine residues . Wnt genes are highly conserved between vertebrate species sharing overall sequence identity and gene structure.nd are slightly less conserved between vertebrates and invertebrates.
  IPR005816:Secreted growth factor Wnt protein
Wnt proteins constitute a large family of secreted molecules that areinvolved in intercellular signalling during development. The name derivesfrom the first 2 members of the family to be discovered: int-1 (mouse) andwingless (Drosophila) . It is now recognised that Wnt signalling controlsmany cell fate decisions in a variety of different organisms.ncludingmammals . Wnt signalling has been implicated in tumorigenesis.arlymesodermal patterning of the embryo.orphogenesis of the brain and kidneys.egulation of mammary gland proliferation and Alzheimers disease .Wnt-mediated signalling is believed to proceed initially through binding tocell surface receptors of the frizzled family; the signal is subsequentlytransduced through several cytoplasmic components to B-catenin.hich entersthe nucleus and activates the transcription of several genes important indevelopment . More recently.owever.everal non-canonical Wntsignalling pathways have been elucidated that act independently ofB-catenin. Members of the Wnt gene family are defined by their sequencesimilarity to mouse Wnt-1 and Wingless in Drosophila. They encode proteinsof ~350-400 residues in length.ith orthologues identified in several.ostly vertebrate.pecies. Very little is known about the structure of Wnts as they are notoriously insoluble; in terms of primary structure.hefamily is characterised by a signal sequence and an almost invariant patternof 23-24 conserved cysteines . Fifteen major Wnt gene families have been identified in vertebrates.ith multiple subtypes within some classes.The Wnt-1 gene was first identified in 1982 as a proto-oncogene activated bythe integration of mouse mammary tumour virus (MMTV) in mammary tumours.With the identification of Drosophila wingless.owever.t became clearthat Wnt genes are important regulators of many developmental decisions.Mutation of the embryonic mouse Wnt-1 gene leads to loss of the midbrain andcerebellum; and a number of processes including segment polarity and limbdevelopment are interrupted in Drosophila wingless mutants .
  IPR009139:Wnt-1 protein
IPR005817:WNT1 
Evalue:-211.52287874528 
Location:60-370IPR009139:WNT1PROTEIN 
Evalue:0 
Location:27-37
SequencesProtein: WNT1_HUMAN (370 aa)
mRNA: NM_005430
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentK03209
  Level 3 annotation:
    wingless-type MMTV integration site family, member 1
  Level 2 annotation:
    Wnt signaling pathway
    Hedgehog signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 101 residues, 47658502-47658804Exon2: 86 residues, 47659517-47659771Exon3: 90 residues, 47660473-47660739Exon4: 517 residues, 47661201-47662746Exon5: 2 residues, -Jump to WNT1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4027 47682322-47698859 ~-17K 8773(PRKAG1)(-)Loci: 4028 47744734-47750042 ~-5K 8775(-)Loci: 4029 47807832-47811571 ~-4K 8784(-)Loci: 4030 47864851-47869128 ~-4K 8785(TUBA3)(-)Loci: 2749 47975175-47978747 ~-4K 8788(PRPH)(+)Loci: 2750 48219206-48238344 ~-19K 8796(KCNH3)(+)Loci: 4031 48546946-48583987 ~-37K 8814(FAIM2)(-)Loci: 2751 48630795-48638929 ~-8K 8815(AQP2)(+)Loci: 2752 48737753-48763660 ~-26K 8820(ACCN2)(+)Loci: 2748 47658502-47662746 ~-4K 8771(WNT1)(+)Link out to UCSC