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0WNK4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameWNK4
DescriptionSerine/threonine-protein kinase wnk4 (ec 2.7.1.37) (protein kinase with no lysine 4) (protein kinase, lysine-deficient 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005923 tight junction (ISS)
0005524 ATP binding (ISS)
0004674 protein serine/threonine kinase activity (ISS)
0006811 ion transport (ISS)
0006468 protein amino acid phosphorylation (ISS)
0007243 protein kinase cascade (ISS)
0050794 regulation of cellular process (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-59.0268707275391 
Location:174-432IPR000719:PROTEIN_KINASE_ATP 
Evalue:0 
Location:0-0
SequencesProtein: WNK4_HUMAN (1243 aa)
mRNA: AJ316534 NM_032387
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentK00870
  Level 3 annotation:
    protein kinase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 214 residues, 38186221-38186860Exon2: 59 residues, 38188301-38188474Exon3: 75 residues, 38189480-38189701Exon4: 54 residues, 38189965-38190123Exon5: 31 residues, 38190640-38190729Exon6: 74 residues, 38190809-38191026Exon7: 90 residues, 38192821-38193086Exon8: 42 residues, 38193321-38193443Exon9: 21 residues, 38193673-38193732Exon10: 41 residues, 38193833-38193951Exon11: 41 residues, 38194224-38194341Exon12: 48 residues, 38199135-38199273Exon13: 20 residues, 38200157-38200212Exon14: 205 residues, 38200315-38200926Exon15: 22 residues, 38201004-38201065Exon16: 138 residues, 38201168-38201577Exon17: 68 residues, 38201666-38201866Exon18: 34 residues, 38202024-38202122Exon19: 127 residues, 38202229-38202605Exon20: 2 residues, -Jump to WNK4_HUMANExon1: 212 residues, 38186227-38186860Exon2: 59 residues, 38188301-38188474Exon3: 75 residues, 38189480-38189701Exon4: 54 residues, 38189965-38190123Exon5: 31 residues, 38190640-38190729Exon6: 74 residues, 38190809-38191026Exon7: 90 residues, 38192821-38193086Exon8: 42 residues, 38193321-38193443Exon9: 21 residues, 38193673-38193732Exon10: 41 residues, 38193833-38193951Exon11: 41 residues, 38194224-38194341Exon12: 48 residues, 38199135-38199273Exon13: 20 residues, 38200157-38200212Exon14: 205 residues, 38200315-38200926Exon15: 22 residues, 38201004-38201065Exon16: 138 residues, 38201168-38201577Exon17: 68 residues, 38201666-38201866Exon18: 34 residues, 38202024-38202122Exon19: 40 residues, 38202229-38202344Exon20: 2 residues, -Jump to WNK4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4288 37562438-37586822 ~-24K 15872(KCNH4)(-)Loci: 4289 37589603-37590996 ~-1K 15873(HCRT)(-)Loci: 3002 37864387-37928122 ~-64K 15882(ATP6V0A1)(+)Loci: 3003 37941476-37949990 ~-9K 15887(NAGLU)(+)Loci: 3004 38064836-38072549 ~-8K 15898(TUBG2)(+)Loci: 3005 38088157-38105358 ~-17K 15903(CNTNAP1)(+)Loci: 4290 38105819-38150574 ~-45K 15904(EZH1)(-)Loci: 3006 38186221-38202605 ~-16K 15907(WNK4)(+)Loci: 4291 38215677-38229807 ~-14K 15912(BECN1)(-)Loci: 3007 38250134-38256248 ~-6K 15916(AOC2)(+)Loci: 3008 38256726-38263664 ~-7K 15917(AOC3)(+)Loci: 4292 38420147-38427921 ~-8K 15927(VAT1)(-)Loci: 4293 38449839-38530657 ~-81K 15931(BRCA1)(-)Loci: 4287 37530523-37560548 ~-30K 15871(RAB5C)(-)Link out to UCSC