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0WNK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSerine/threonine-protein kinase wnk1 (ec (protein kinase with no lysine 1) (protein kinase, lysine-deficient 1) (kinase deficient protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (IDA)
0005524 ATP binding (IDA)
0005515 protein binding (IPI)
0004674 protein serine/threonine kinase activity (IDA)
0006811 ion transport (ISS)
0006468 protein amino acid phosphorylation (IDA)
0007243 protein kinase cascade (IDA)
0050794 regulation of cellular process (ISS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
SequencesProtein: WNK1_HUMAN (2382 aa)
mRNA: NM_018979
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 254 residues, 732992-733751Exon2: 59 residues, 793068-793241Exon3: 75 residues, 806468-806689Exon4: 54 residues, 809429-809587Exon5: 31 residues, 836587-836676Exon6: 75 residues, 838671-838891Exon7: 112 residues, 840439-840770Exon8: 64 residues, 841509-841697Exon9: 30 residues, 850691-850775Exon10: 52 residues, 857638-857788Exon11: 155 residues, 858999-859458Exon12: 95 residues, 860147-860426Exon13: 34 residues, 861118-861216Exon14: 56 residues, 861337-861500Exon15: 41 residues, 862369-862486Exon16: 60 residues, 862821-862995Exon17: 21 residues, 863200-863258Exon18: 43 residues, 863547-863670Exon19: 480 residues, 864075-865511Exon20: 30 residues, 866647-866731Exon21: 30 residues, 868566-868650Exon22: 22 residues, 869879-869940Exon23: 26 residues, 873988-874062Exon24: 222 residues, 875497-876159Exon25: 69 residues, 876905-877108Exon26: 67 residues, 879902-880097Exon27: 64 residues, 887273-887461Exon28: 108 residues, 887901-888219Exon29: 2 residues, -Jump to WNK1_HUMAN  
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