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0WDR7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameWDR7
DescriptionWd-repeat protein 7 (tgf-beta resistance-associated protein trag) (rabconnectin-3 beta).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase.ype II includes soluble quinohaemoprotein with a C-terminal containing haem C.nd type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain . These quinoproteins contain an 8-bladed beta-propeller motif.hich is present in the N-terminal domain of quinoprotein alcohol dehydrogenase.thanol dehydrogenase.nd the heavy chain (alpha subunit) of methanol dehydrogenase () .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011047:Quinonprotein alcohol dehydrogenase-like
IPR001680:WD40 
Evalue:-5.82390874094432 
Location:1383-1423IPR001680:WD40 
Evalue:-5.63827228546143 
Location:454-498IPR001680:WD40 
Evalue:-4.30103015899658 
Location:550-588IPR001680:WD40 
Evalue:-3.60206007957458 
Location:9-47IPR001680:WD40 
Evalue:-3.35654735565186 
Location:54-95IPR001680:WD40 
Evalue:1.6232492903979 
Location:501-546IPR001680:WD40 
Evalue:2.25527250510331 
Location:208-242
SequencesProtein: WDR7_HUMAN (1490 aa)
mRNA: NM_015285
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 65 residues, 52469613-52469805Exon2: 61 residues, 52490725-52490903Exon3: 37 residues, 52497560-52497667Exon4: 28 residues, 52499541-52499620Exon5: 60 residues, 52500907-52501082Exon6: 27 residues, 52504184-52504261Exon7: 42 residues, 52505083-52505203Exon8: 50 residues, 52509444-52509590Exon9: 36 residues, 52509943-52510046Exon10: 49 residues, 52512847-52512989Exon11: 85 residues, 52513178-52513427Exon12: 75 residues, 52514470-52514691Exon13: 67 residues, 52536192-52536388Exon14: 73 residues, 52549611-52549826Exon15: 258 residues, 52574811-52575581Exon16: 31 residues, 52577093-52577182Exon17: 35 residues, 52595010-52595109Exon18: 41 residues, 52597659-52597778Exon19: 43 residues, 52599761-52599885Exon20: 40 residues, 52634259-52634373Exon21: 76 residues, 52698172-52698394Exon22: 64 residues, 52742150-52742337Exon23: 41 residues, 52754016-52754134Exon24: 52 residues, 52756761-52756911Exon25: 29 residues, 52757539-52757622Exon26: 35 residues, 52780658-52780758Exon27: 37 residues, 52838973-52839078Exon28: 936 residues, 52845232-52848034Exon29: 2 residues, -Jump to WDR7_HUMAN  
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