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0WDFY1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameWDFY1
DescriptionWd repeat and fyve domain containing protein 1 (wd40- and fyve-domain containing protein 1) (phosphoinositide-binding protein 1) (fens-1) (zinc finger fyve domain containing protein 17).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005829 cytosol (IDA)
0005769 early endosome (IDA)
0005634 nucleus (IDA)
0005545 phosphatidylinositol binding (IDA)
0008270 zinc ion binding (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The FYVE zinc finger is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. The FYVE finger has been shown to bind two Zn2+ ions . The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG.here + represents a charged residue and X any residue.
  IPR000306:Zinc finger, FYVE-type
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR000306:FYVE 
Evalue:-23.1023731231689 
Location:279-353IPR001680:WD40 
Evalue:-8.09691047668457 
Location:189-227IPR001680:WD40 
Evalue:-3.42021632194519 
Location:14-52IPR001680:WD40 
Evalue:-2.95860731484177 
Location:231-270IPR001680:WD40 
Evalue:-2.82390880584717 
Location:356-394IPR001680:WD40 
Evalue:-1.49485003948212 
Location:104-138IPR001680:WD40 
Evalue:1.74036268949424 
Location:56-96IPR001680:WD40 
Evalue:2.14612803567824 
Location:145-183
SequencesProtein: WDFY1_HUMAN (410 aa)
mRNA: NM_020830
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1128 residues, 224448309-224451691Exon2: 38 residues, 224453084-224453193Exon3: 45 residues, 224454902-224455033Exon4: 36 residues, 224457608-224457710Exon5: 37 residues, 224467194-224467300Exon6: 44 residues, 224468464-224468591Exon7: 39 residues, 224471918-224472031Exon8: 52 residues, 224474143-224474294Exon9: 20 residues, 224478907-224478962Exon10: 26 residues, 224485213-224485287Exon11: 24 residues, 224490903-224490971Exon12: 64 residues, 224518108-224518296Exon13: 2 residues, -Jump to WDFY1_HUMAN  
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