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0WASIP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameWASPIP
DescriptionWiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015629 actin cytoskeleton (TAS)
0003779 actin binding (TAS)
0005522 profilin binding (TAS)
0008154 actin polymerization and/or depolymerization (TAS)
0006461 protein complex assembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The WH2 (WASP-Homology 2.r Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals.n insect viruses.nd in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain and with the CRIB domain.nd the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments .
  IPR003124:Actin-binding WH2
IPR003124:WH2 
Evalue:-4.01772880554199 
Location:32-49
SequencesProtein: WASIP_HUMAN (503 aa)
mRNA: BX640870 NM_003387
Local Annotation
Synapse Ontology
actin exists in two states within the cell: as polymerized two-stranded helical filaments (F-actin) or as monomers (Gactin), which provide the building blocks for filament assembly.
sdb:0283 G-actin  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1010 residues, 175132548-175135576Exon2: 40 residues, 175140043-175140157Exon3: 73 residues, 175140834-175141047Exon4: 259 residues, 175144649-175145420Exon5: 61 residues, 175148177-175148354Exon6: 45 residues, 175154283-175154413Exon7: 31 residues, 175158496-175158585Exon8: 21 residues, 175207491-175207550Exon9: 2 residues, -Jump to WASIP_HUMANExon1: 453 residues, 175133743-175135099Exon2: 19 residues, 175135524-175135576Exon3: 40 residues, 175140043-175140157Exon4: 73 residues, 175140834-175141047Exon5: 259 residues, 175144649-175145420Exon6: 61 residues, 175148177-175148354Exon7: 45 residues, 175154283-175154413Exon8: 31 residues, 175158496-175158585Exon9: 44 residues, 175255747-175255873Exon10: 2 residues, -Jump to WASIP_HUMAN  
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Loci Cluster (Details)Loci: 4480 175320852-175337416 ~-17K 21613(CHRNA1)(-)Loci: 4481 175372337-175578361 ~-206K 21615(CHN1)(-)Loci: 4482 175647253-175741143 ~-94K 21619(ATF2)(-)Loci: 4479 175132548-175255873 ~-123K 21610(WASPIP)(-)Link out to UCSC