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0WASF3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameWASF3
DescriptionWiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (wave-3 protein) (verprolin homology domain-containing protein 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030041 actin filament polymerization (TAS)
0006461 protein complex assembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The WH2 (WASP-Homology 2.r Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals.n insect viruses.nd in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain and with the CRIB domain.nd the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments .
  IPR003124:Actin-binding WH2
IPR003124:WH2 
Evalue:-6.25181198120117 
Location:440-457
SequencesProtein: WASF3_HUMAN (502 aa)
mRNA: AB020707
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK06083
  Level 3 annotation:
    WAS protein family, member 3
  Level 2 annotation:
    Adherens junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 26085096-26085195Exon2: 49 residues, 26114397-26114540Exon3: 47 residues, 26137164-26137299Exon4: 53 residues, 26139653-26139807Exon5: 41 residues, 26144008-26144126Exon6: 60 residues, 26148685-26148861Exon7: 91 residues, 26153190-26153457Exon8: 124 residues, 26154743-26155111Exon9: 1081 residues, 26157824-26161063Exon10: 2 residues, -Jump to WASF3_HUMAN  
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