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0WASF2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionWiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (wave-2 protein) (verprolin homology domain-containing protein 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015629 actin cytoskeleton (TAS)
0003779 actin binding (TAS)
0030036 actin cytoskeleton organization and biogenesis (TAS)
0007188 G-protein signaling, coupled to cAMP nucleo... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Histamine is distributed within mast cells in all peripheral tissues and is a well-characterised mediator of inflammation and allergy . It also regulates release of gastric acid from parietal cells in the gastric mucosa. H3 receptors function as presynaptic autoreceptors on histamine-containing neurones. They are expressed abundantly in the central nervous system.ith highest levels found in the thalamus.audate nucleus and cortex. High levels of expression are also found in the hypothalamus.ippocampus and olfactory tubercle. In the periphery.ow levels of H3 have been detected in the human small intestine.estis and prostate but not in a number of other tissues tested.ncluding the heart.ung and spleen . Binding of histamine to H3 receptors results in inhibition of forskolin-stimulated cAMP accumulation.uggesting coupling to a G-protein of the Gi class .
  IPR003980:Histamine H3 receptor
InterPro domains unassigned to SynO:
The WH2 (WASP-Homology 2.r Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals.n insect viruses.nd in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain and with the CRIB domain.nd the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments .
  IPR003124:Actin-binding WH2
Extensins are plant cell-wall proteins; they can account for up to 20% ofthe dry weight of the cell wall. They are highly-glycosylated.ossiblyreflecting their interactions with cell-wall carbohydrates. Amongst their functions is cell wall strengthening in response to mechanical stress (e.g..uring attack by pests.lant-bending in the contrast with extensin genes.istil-specific extensin-like genes arenot induced under stress conditions. Gene expression is organ-specific and temporally regulated during pistil development. After pollination.ranscript levels of pistil-specific extensin-like genes change relative tolevels in unpollinated pistils . The protein sequence is characterisedby multiple tandem ser-pro-pro-pro-pro pentapeptide repeats.
  IPR003882:Pistil-specific extensin-like protein
SequencesProtein: WASF2_HUMAN (498 aa)
mRNA: NM_006990
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
KO assignmentK05748
  Level 3 annotation:
    WAS protein family, member 2
  Level 2 annotation:
    Regulation of actin cytoskeleton
    Adherens junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 906 residues, 27604712-27607427Exon2: 173 residues, 27608772-27609287Exon3: 54 residues, 27611652-27611808Exon4: 45 residues, 27613913-27614044Exon5: 41 residues, 27615065-27615183Exon6: 53 residues, 27617356-27617510Exon7: 47 residues, 27618041-27618176Exon8: 59 residues, 27627857-27628030Exon9: 59 residues, 27689083-27689256Exon10: 2 residues, -Jump to WASF2_HUMAN  
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Loci Cluster (Details)Loci: 2494 27120810-27145474 ~-25K 818(NUDC)(+)Loci: 2495 27192784-27199731 ~-7K 822(+)Loci: 2496 27541099-27553008 ~-12K 833(SYTL1)(+)Loci: 3786 27604712-27689256 ~-85K 852(WASF2)(-)Loci: 2497 27972369-28023401 ~-51K 864(STX12)(+)Loci: 3787 28173405-28287718 ~-114K 879(EYA3)(-)Loci: 2493 27062219-27063534 ~-1K 814(SFN)(+)Link out to UCSC