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0VTI1A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVTI1A
DescriptionVesicle transport through interaction with t-snares homolog 1a (vesicle transport v-snare protein vti1-like 2) (vti1-rp2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008565 protein transporter activity (NAS)
0015031 protein transport (NAS)
0016192 vesicle-mediated transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
A crucial step in membrane fusion is the formation of the SNARE complex in which conserved regions.alled SNARE motifs.rom individual SNAREs associate and twist to form the core complex.hich is an all-parallel coiled coil. The neuronal SNARE complex is a heterotrimer of vesicular (v-) SNARE VAMP-2 and the two target plasma membrane (t-) SNAREssyntaxin 1A and SNAP-25. It has been proposed that SNARE core complex formation proceeds like a zipper.eginning at themembrane-distal region and propagating toward themembrane-proximal end. SNARE complex formation is an energy-releasing process that may supply the required freeenergy for membrane fusion .This family includes the Golgi SNAP receptor (SNARE) complex protein.hich is involved in transport from the endoplasmic reticulum to the golgi apparatus and intra-golgi transport.nd the vesicle transport v-SNARE protein.hat mediates vesicle transport pathways through interaction with T-SNAREs on the target membrane.
  IPR007705:Vesicle transport v-SNARE
The process of vesicular fusion with target membranes depends on a set of SNAREs (SNAP-Receptors).hich are associated with the fusing membranes . Target SNAREs (t-SNAREs) are localised on the target membrane and belong to two different families.he syntaxin-like family and the SNAP-25 like family. One member of each family.ogether with av-SNARE localised on the vesicular membrane.re required for fusion. The Syntaxins are type-I transmembrane proteins that contain several regions with coiled-coil propensity in their cytosolic part.he SNARE motif. SNAP-25 () is a protein consisting of two coiled-coil regions.hich is associated with the membrane by lipid anchors. SNARE motifs assemble into parallel four helix bundles stabilised by the burial of these hydrophobic helix faces in the bundle core. Monomeric SNARE motifs are disordered so this assembly reaction is accompanied by a dramatic increase in alpha-helical secondary structure . The parallel arrangement of SNARE motifs within complexes bring the transmembrane anchors.nd the two membranes.nto close proximity. Recently.t was shown that the two coiled-coil regions of SNAP-25 andone of the coiled-coil regions of the syntaxins are related . This domain is found in both Syntaxin and SNAP-25 families as well as in other proteins.
  IPR000727:Target SNARE coiled-coil region
IPR007705:V-SNARE 
Evalue:-51.9586067199707 
Location:41-187
SequencesProtein: VTI1A_HUMAN (203 aa)
mRNA: NM_145206
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 71 residues, 114197005-114197215Exon2: 21 residues, 114210272-114210331Exon3: 39 residues, 114214295-114214406Exon4: 28 residues, 114276835-114276913Exon5: 30 residues, 114287994-114288079Exon6: 25 residues, 114417966-114418037Exon7: 22 residues, 114418685-114418747Exon8: 352 residues, 114486471-114487522Exon9: 2 residues, -Jump to VTI1A_HUMAN  
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Loci Cluster (Details)Loci: 2634 114125012-114178127 ~-53K 5715(ACSL5)(+)Loci: 2635 114197005-114487522 ~-291K 5719(VTI1A)(+)Loci: 3921 113899611-113933508 ~-34K 5712(GPAM)(-)Link out to UCSC