SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0VPS45_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVPS45A
DescriptionVacuolar protein sorting-associated protein 45 (h-vps45) (hlvps45).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005798 Golgi vesicle (TAS)
0005764 lysosome (TAS)
0006954 inflammatory response (TAS)
0006886 intracellular protein transport (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1901758177.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis . They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation. protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events.heir interaction with syntaxin molecules seems to represent a negative regulatory step in secretion .
  IPR001619:Sec1-like protein
IPR001619:Sec1 
Evalue:-242.346786499023 
Location:22-547
SequencesProtein: VPS45_HUMAN (570 aa)
mRNA: NM_007259
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
endosomal intermediate functions as a sorting station before be redirected into the recycling vesicle population.
sdb:0150 endosomal intermediate  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 49 residues, 148306486-148306631Exon2: 47 residues, 148307310-148307445Exon3: 22 residues, 148310856-148310917Exon4: 28 residues, 148314934-148315014Exon5: 25 residues, 148315617-148315686Exon6: 48 residues, 148315795-148315933Exon7: 39 residues, 148316370-148316481Exon8: 47 residues, 148320047-148320182Exon9: 40 residues, 148320589-148320703Exon10: 58 residues, 148321423-148321591Exon11: 55 residues, 148330654-148330813Exon12: 38 residues, 148331019-148331127Exon13: 42 residues, 148332246-148332368Exon14: 46 residues, 148349234-148349366Exon15: 208 residues, 148383510-148384128Exon16: 2 residues, -Jump to VPS45_HUMAN  
Tune and view alternative isoforms