SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0VPS39_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVPS39
DescriptionVam6/vps39-like protein (hvam6p).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Based on sequence similarities a domain of homology has been identified in the following proteins :Citron and Citron kinase. These two proteins interact with the GTP-bound forms of the small GTPases Rho and Rac but not with Cdc42.Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCKalpha). This serine/threonine kinase interacts with the GTP-bound form of the small GTPase Cdc42 and to a lesser extent with that of Rac.NCK Interacting Kinase (NIK). serine/threonine protein kinase.ROM-1 and ROM-2.rom yeast. These proteins are GDP/GTP exchange proteins (GEPs) for the small GTP binding protein Rho1.This domain.alled the citron homology domain.s often found after cysteine rich and pleckstrin homology (PH) domains at the C-terminal end of the proteins . It acts as a regulatory domain and could be involved in macromolecular interactions .
  IPR001180:Citron-like
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR001180:CNH 
Evalue:-6.56863641738892 
Location:15-294
SequencesProtein: VPS39_HUMAN (886 aa)
mRNA: NM_015289
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 710 residues, 40238191-40240319Exon2: 32 residues, 40241171-40241263Exon3: 47 residues, 40241521-40241656Exon4: 52 residues, 40241821-40241971Exon5: 17 residues, 40242839-40242885Exon6: 36 residues, 40243115-40243218Exon7: 45 residues, 40243847-40243976Exon8: 41 residues, 40244485-40244603Exon9: 35 residues, 40245207-40245306Exon10: 26 residues, 40245648-40245722Exon11: 31 residues, 40246052-40246139Exon12: 49 residues, 40246261-40246403Exon13: 50 residues, 40246883-40247027Exon14: 49 residues, 40249213-40249356Exon15: 45 residues, 40253212-40253342Exon16: 42 residues, 40257707-40257828Exon17: 42 residues, 40257939-40258060Exon18: 63 residues, 40264006-40264190Exon19: 33 residues, 40266760-40266853Exon20: 35 residues, 40267247-40267346Exon21: 33 residues, 40268603-40268698Exon22: 16 residues, 40270614-40270657Exon23: 23 residues, 40270985-40271050Exon24: 24 residues, 40279385-40279451Exon25: 76 residues, 40287570-40287794Exon26: 2 residues, -Jump to VPS39_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2879 39907605-39927630 ~-20K 12149(+)Loci: 4164 39927636-39973567 ~-46K 12151(SPTBN5)(-)Loci: 4165 40238191-40287794 ~-50K 12159(VPS39)(-)Loci: 2880 40438989-40491807 ~-53K 12167(CAPN3)(+)Loci: 2881 40575126-40612548 ~-37K 12175(SNAP23)(+)Loci: 2882 40655148-40752587 ~-97K 12179(+)Loci: 2878 39638523-39658828 ~-20K 12142(TYRO3)(+)Link out to UCSC