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0VPS16_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVPS16
DescriptionVacuolar protein sorting 16 (hvps16).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting.hich is essential for viability in plants.ut not yeast . The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport . The role of VPS16 in this complex is not known.
  IPR006926:Vps16, N-terminal
This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting.hich is essential for viability in plants.ut not yeast . The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport . The role of VPS16 in this complex is not known.
  IPR006925:Vps16, C-terminal
IPR006926:Vps16_N 
Evalue:-270.431793212891 
Location:4-420IPR006925:Vps16_C 
Evalue:-202.769546508789 
Location:517-835
SequencesProtein: VPS16_HUMAN (839 aa)
mRNA: NM_022575
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 2769372-2769473Exon2: 31 residues, 2788364-2788453Exon3: 34 residues, 2788699-2788797Exon4: 45 residues, 2788884-2789013Exon5: 50 residues, 2789094-2789239Exon6: 40 residues, 2789393-2789509Exon7: 43 residues, 2789615-2789738Exon8: 20 residues, 2789870-2789926Exon9: 32 residues, 2790260-2790350Exon10: 33 residues, 2790450-2790545Exon11: 27 residues, 2790699-2790776Exon12: 46 residues, 2791224-2791356Exon13: 44 residues, 2791452-2791580Exon14: 14 residues, 2791710-2791746Exon15: 38 residues, 2791935-2792044Exon16: 47 residues, 2792594-2792729Exon17: 38 residues, 2792824-2792933Exon18: 34 residues, 2793010-2793108Exon19: 38 residues, 2793192-2793300Exon20: 28 residues, 2793623-2793701Exon21: 58 residues, 2793793-2793963Exon22: 34 residues, 2794044-2794141Exon23: 36 residues, 2794857-2794961Exon24: 102 residues, 2795075-2795377Exon25: 2 residues, -Jump to VPS16_HUMAN  
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Loci Cluster (Details)Loci: 3230 2769372-2795377 ~-26K 22579(VPS16)(+)Loci: 3229 2465252-2570430 ~-105K 22557(TMC2)(+)Link out to UCSC