SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0VPP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameATP6V0A1
DescriptionVacuolar proton translocating atpase 116 kda subunit a isoform 1 (v- atpase 116-kda isoform a1) (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient.sing the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse.sing the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases.hich can differ in function (ATP synthesis and/or hydrolysis).tructure (F-.- and A-ATPases contain rotary motors) and in the type of ions they transport . F-ATPases (F1F0-ATPases) in mitochondria.hloroplasts and bacterial plasma membranes are the prime producers of ATP.sing the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases) are primarily found in eukaryotic vacuoles.atalysing ATP hydrolysis to transport solutes and lower pH in organelles.A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases.P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles.nd function to transport a variety of different ions across membranes.E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs.ncluding extracellular ATP.The V-ATPases (or V1V0-ATPase) and A-ATPases (or A1A0-ATPase) are each composed of two linked complexes: the V1 or A1 complex contains the catalytic core that hydrolyses/synthesizes ATP.nd the V0 or A0 complex that forms the membrane-spanning pore. The V- and A-ATPases both contain rotary motors.ne that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis . The V- and A-ATPases more closely resemble one another in subunit structure than they do the F-ATPases.lthough the function of A-ATPases is closer to that of F-ATPases. This entry represents the 116-kDa subunit (or subunit a) and subunit I found in the V0 or A0 complex of V- or A-ATPases.espectively. The 116-kDa subunit is a transmembrane glycoprotein required for the assembly and proton transport activity of the ATPase complex. Several isoforms of the 116-kDa subunit exist.roviding a potential role in the differential targeting and regulation of the V-ATPase for specific organelles .More information about this protein can be found at Protein of the Month: ATP Synthases .
  IPR002490:ATPase, V0/A0 complex, 116-kDa subunit
The Prefoldin/GimC family of proteins are found in eukaryotes and archaea . Prefoldin is part of a molecular chaperone system that promotes the correct folding of nascent polypeptide chains. Prefoldin/GimC interacts with the nascent chain to stabilise it prior to its folding within the central cavity of a chaperonin. Prefoldin/GimC is a hexamer consisting of two types of subunits.lpha and beta. Archaeal prefoldin contains one type of alpha and one type of beta subunit .hile eukaryotic prefoldin/GimC contains two different but related alpha subunits and four related beta subunits .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009053:Prefoldin
IPR002490:V_ATPase_I 
Evalue:-1e+125 
Location:26-828
SequencesProtein: VPP1_HUMAN (837 aa)
mRNA: BC032398 NM_005177
Local Annotation
Synapse Ontology
A clathrin coat found on a synaptic vesicle.
sdb:0076 clathrin coat of synaptic vesicle  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
interaction between synaptic vesicle and the scaffold.
sdb:0106 transport of synaptic vesicle in the presynaptic axon  (Evidence:keywords)
KO assignmentK02154
  Level 3 annotation:
    V-type H+-transporting ATPase subunit I
  Level 2 annotation:
    ATP synthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 37864387-37864507Exon2: 56 residues, 37866391-37866555Exon3: 28 residues, 37871972-37872051Exon4: 34 residues, 37873553-37873651Exon5: 45 residues, 37875633-37875762Exon6: 29 residues, 37883203-37883286Exon7: 44 residues, 37884006-37884133Exon8: 29 residues, 37886210-37886293Exon9: 33 residues, 37888581-37888675Exon10: 73 residues, 37892698-37892911Exon11: 52 residues, 37896030-37896181Exon12: 48 residues, 37899877-37900017Exon13: 53 residues, 37900577-37900732Exon14: 32 residues, 37901169-37901260Exon15: 41 residues, 37904467-37904586Exon16: 74 residues, 37906250-37906467Exon17: 38 residues, 37906740-37906848Exon18: 38 residues, 37913063-37913171Exon19: 41 residues, 37919404-37919522Exon20: 59 residues, 37919832-37920004Exon21: 519 residues, 37926570-37928122Exon22: 2 residues, -Jump to VPP1_HUMANExon1: 18 residues, 37864455-37864507Exon2: 56 residues, 37866391-37866555Exon3: 28 residues, 37871972-37872051Exon4: 34 residues, 37873553-37873651Exon5: 45 residues, 37875633-37875762Exon6: 29 residues, 37883203-37883286Exon7: 44 residues, 37884006-37884133Exon8: 29 residues, 37886210-37886293Exon9: 33 residues, 37888581-37888675Exon10: 73 residues, 37892698-37892911Exon11: 52 residues, 37896030-37896181Exon12: 48 residues, 37899877-37900017Exon13: 53 residues, 37900577-37900732Exon14: 32 residues, 37901169-37901260Exon15: 41 residues, 37904467-37904586Exon16: 74 residues, 37906250-37906467Exon17: 38 residues, 37906740-37906848Exon18: 38 residues, 37913063-37913171Exon19: 8 residues, 37914115-37914133Exon20: 41 residues, 37919404-37919522Exon21: 59 residues, 37919832-37920004Exon22: 519 residues, 37926570-37928122Exon23: 2 residues, -Jump to VPP1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4288 37562438-37586822 ~-24K 15872(KCNH4)(-)Loci: 4289 37589603-37590996 ~-1K 15873(HCRT)(-)Loci: 3002 37864387-37928122 ~-64K 15882(ATP6V0A1)(+)Loci: 3003 37941476-37949990 ~-9K 15887(NAGLU)(+)Loci: 3004 38064836-38072549 ~-8K 15898(TUBG2)(+)Loci: 3005 38088157-38105358 ~-17K 15903(CNTNAP1)(+)Loci: 4290 38105819-38150574 ~-45K 15904(EZH1)(-)Loci: 3006 38186221-38202605 ~-16K 15907(WNK4)(+)Loci: 4291 38215677-38229807 ~-14K 15912(BECN1)(-)Loci: 3007 38250134-38256248 ~-6K 15916(AOC2)(+)Loci: 3008 38256726-38263664 ~-7K 15917(AOC3)(+)Loci: 4292 38420147-38427921 ~-8K 15927(VAT1)(-)Loci: 4293 38449839-38530657 ~-81K 15931(BRCA1)(-)Loci: 4287 37530523-37560548 ~-30K 15871(RAB5C)(-)Link out to UCSC