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0VP33A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVPS33A
DescriptionVacuolar protein sorting 33a (hvps33a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis . They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation. protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events.heir interaction with syntaxin molecules seems to represent a negative regulatory step in secretion .
  IPR001619:Sec1-like protein
IPR001619:Sec1 
Evalue:-224.468521118164 
Location:33-591
SequencesProtein: VP33A_HUMAN (596 aa)
mRNA: AK026840 NM_022916
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 294 residues, 121282046-121282927Exon2: 58 residues, 121283299-121283468Exon3: 48 residues, 121286285-121286423Exon4: 48 residues, 121289086-121289224Exon5: 24 residues, 121290377-121290445Exon6: 44 residues, 121292881-121293008Exon7: 66 residues, 121295068-121295262Exon8: 60 residues, 121300370-121300545Exon9: 41 residues, 121301482-121301599Exon10: 64 residues, 121311760-121311947Exon11: 44 residues, 121314071-121314199Exon12: 24 residues, 121314633-121314699Exon13: 44 residues, 121316806-121316932Exon14: 2 residues, -Jump to VP33A_HUMANExon1: 294 residues, 121282046-121282927Exon2: 58 residues, 121283299-121283468Exon3: 48 residues, 121286285-121286423Exon4: 48 residues, 121289086-121289224Exon5: 24 residues, 121290377-121290445Exon6: 44 residues, 121292881-121293008Exon7: 66 residues, 121295068-121295262Exon8: 60 residues, 121300370-121300545Exon9: 41 residues, 121301482-121301599Exon10: 64 residues, 121311760-121311947Exon11: 44 residues, 121314071-121314199Exon12: 24 residues, 121314633-121314699Exon13: 56 residues, 121316806-121316970Exon14: 2 residues, -Jump to VP33A_HUMAN  
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Loci Cluster (Details)Loci: 4084 121282046-121316970 ~-35K 9906(VPS33A)(-)Loci: 2797 121577761-121676899 ~-99K 9919(KNTC1)(+)Loci: 2798 121885991-121913460 ~-27K 9929(HIP1R)(+)Loci: 4083 121258162-121276552 ~-18K 9902(DIABLO)(-)Link out to UCSC