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0VMAT2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC18A2
DescriptionSynaptic vesicular amine transporter (monoamine transporter) (vesicular amine transporter 2) (vat2) (solute carrier family 18 member 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0008504 monoamine transporter activity (TAS)
0015844 monoamine transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Among the different families of transporter only two occur ubiquitously in all classifications of organisms. These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients .
  IPR011701:Major facilitator superfamily MFS_1
IPR011701:MFS_1 
Evalue:-42.0915145874023 
Location:26-445
SequencesProtein: VMAT2_HUMAN (514 aa)
mRNA: BC030593 NM_003054
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
interaction between synaptic vesicle and the scaffold.
sdb:0106 transport of synaptic vesicle in the presynaptic axon  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK08155
  Level 3 annotation:
    MFS transporter, DHA1 family, solute carrier family 18 (vesicular monoamine)
  Level 2 annotation:
    Major facilitator superfamily (MFS)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 43 residues, 118990593-118990721Exon2: 47 residues, 118991179-118991315Exon3: 116 residues, 118993471-118993814Exon4: 21 residues, 119002899-119002958Exon5: 152 residues, 119003548-119003998Exon6: 32 residues, 119004777-119004867Exon7: 16 residues, 119004979-119005023Exon8: 22 residues, 119005097-119005158Exon9: 34 residues, 119007297-119007393Exon10: 28 residues, 119016233-119016312Exon11: 19 residues, 119016484-119016536Exon12: 23 residues, 119017173-119017237Exon13: 42 residues, 119019571-119019691Exon14: 46 residues, 119019830-119019964Exon15: 758 residues, 119026662-119028931Exon16: 2 residues, -Jump to VMAT2_HUMANExon1: 6 residues, 118990705-118990721Exon2: 47 residues, 118991179-118991315Exon3: 116 residues, 118993471-118993814Exon4: 21 residues, 119002899-119002958Exon5: 30 residues, 119003548-119003632Exon6: 33 residues, 119003905-119003998Exon7: 32 residues, 119004777-119004867Exon8: 16 residues, 119004979-119005023Exon9: 22 residues, 119005097-119005158Exon10: 34 residues, 119007297-119007393Exon11: 28 residues, 119016233-119016312Exon12: 19 residues, 119016484-119016536Exon13: 23 residues, 119017173-119017237Exon14: 42 residues, 119019571-119019691Exon15: 46 residues, 119019830-119019964Exon16: 143 residues, 119026662-119027085Exon17: 2 residues, -Jump to VMAT2_HUMAN  
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Loci Cluster (Details)Loci: 2637 119291945-119299043 ~-7K 5787(EMX2)(+)Loci: 2636 118990593-119028931 ~-38K 5784(SLC18A2)(+)Link out to UCSC