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0VEGFB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionVascular endothelial growth factor b precursor (vegf-b) (vegf related factor) (vrf).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
0005172 vascular endothelial growth factor receptor... (NAS)
0008284 positive regulation of cell proliferation (TAS)
0001558 regulation of cell growth (NAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Platelet-derived growth factor (PDGF) .s a potent mitogen for cells ofmesenchymal origin.ncluding smooth muscle cells and glial cells. In both mouse and human.he PDGF signalling network consists of four ligands.DGFA-D.nd two receptors.DGFRalpha and PDGFRbeta. All PDGFs function as secreted.isulfide-linkedhomodimers.ut only PDGFA and B can form functional heterodimers. PDGFRs also function as homo- and heterodimers. All known PDGFs have characteristic PDGF domains.hich include eight conserved cysteines that are involved in inter- and intramolecular bonds.Alternate splicing of the A chain transcript can give rise to two differentforms that differ only in their C-terminal extremity. The transforming proteinof simian sarcoma virus (SSV).ncoded by the v-sis oncogene.s derived from the B chain of PDGF.PDGFs are mitogenic during early developmental stages.riving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages.DGF signalling has been implicated in tissue remodelling and cellular differentiation.nd in inductive events involved in patterning and morphogenesis. In addition to drivingmesenchymal proliferation.DGFs have been shown to direct the migration.ifferentiation and function of a variety of specialised mesenchymal and migratory cell types.oth during development and in theadult animal . Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B.EGF-C) .hich are active in angiogenesis and endothelial cell growth.nd placenta growth factor (PlGF) which is also active in angiogenesis . PDGF is structurally related to a number of other growth factors which also form disulphide-linked homo- or heterodimers.
  IPR000072:Platelet-derived growth factor (PDGF)
The crystal structures of several proteins have been reported as having unusual folds.nvolving intramolecular disulphide bridges. In transforming growth factor-beta 2 (TGF-beta2) .latelet-derived growth factor (PDGF).erve growth factor (NGF) and human chorionic gonadotropin (hCG) .ix conserved cysteines (I to VI in sequence order) form three disulphide links arranged in a knot-like topology. Cystines [II-V] and [III-VI] form a ring of eight amino acids through which the remaining disulphide bond (Cys[I-IV]) penetrates.A similar knotted arrangement of disulphide bonds has been noted in the structures of some enzyme inhibitors and neurotoxins that bind to voltage- gated Ca2+ channels . In those sequences.owever.he cystine topology differs. Cys[III-VI] penetrates a macrocyclic ring formed by Cys[I-IV] and Cys[II-V]. Thus.ystine knots fall into two structural classes: growth factor type and inhibitor-like cystine knots .All growth factor cystine knots structures have similar topology.ith two distorted beta-hairpin loops "above" the knot and a single loop "below". The sizes of the hairpin loop vary significantly.
  IPR002400:Growth factor, cystine knot
SequencesProtein: VEGFB_HUMAN (207 aa)
mRNA: NM_003377
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 63758841-63758941Exon2: 16 residues, 63759505-63759548Exon3: 67 residues, 63759860-63760057Exon4: 26 residues, 63760301-63760375Exon5: 14 residues, 63761234-63761270Exon6: 80 residues, 63761467-63761703Exon7: 145 residues, 63762403-63762834Exon8: 2 residues, -Jump to VEGFB_HUMAN  
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Loci Cluster (Details)Loci: 2672 63498654-63500590 ~-2K 6992(COX8A)(+)Loci: 2673 63758841-63762834 ~-4K 7008(VEGFB)(+)Loci: 2674 63775570-63791969 ~-16K 7011(PLCB3)(+)Loci: 2675 63883200-63896262 ~-13K 7031(RPS6KA4)(+)Loci: 3958 64130223-64247236 ~-117K 7042(NRXN2)(-)Loci: 3959 64376783-64402767 ~-26K 7059(EHD1)(-)Loci: 2676 64551485-64564618 ~-13K 7071(SNX15)(+)Loci: 2677 64635935-64640274 ~-4K 7081(TM7SF2)(+)Loci: 2678 64705918-64736052 ~-30K 7088(CAPN1)(+)Loci: 2679 65049159-65062750 ~-14K 7102(+)Loci: 3960 65121802-65138296 ~-16K 7115(MAP3K11)(-)Loci: 3961 65407787-65412586 ~-5K 7136(FIBP)(-)Loci: 3962 65416267-65424573 ~-8K 7139(FOSL1)(-)Loci: 2680 65594399-65768789 ~-174K 7153(PACS1)(+)Loci: 2681 65792680-65801537 ~-9K 7155(RAB1B)(+)Loci: 2682 65815916-65820707 ~-5K 7159(+)Loci: 3963 65856117-65860576 ~-4K 7162(RIN1)(-)Loci: 2683 66140672-66151387 ~-11K 7189(RBM14)(+)Loci: 2684 66162753-66170514 ~-8K 7192(RBM4)(+)Loci: 3964 66209298-66245446 ~-36K 7194(SPTBN2)(-)Loci: 3965 66372572-66478456 ~-106K 7198(PC)(-)Loci: 2685 66547466-66574905 ~-27K 7200(SYT12)(+)Loci: 2686 66580896-66596059 ~-15K 7201(RHOD)(+)Loci: 3966 66922227-66925952 ~-4K 7219(PPP1CA)(-)Loci: 2687 66979393-66983261 ~-4K 7229(CABP4)(+)Loci: 2688 67130982-67136581 ~-6K 7239(NDUFV1)(+)Loci: 2689 67554684-67560690 ~-6K 7248(NDUFS8)(+)Loci: 2690 67836710-67973317 ~-137K 7259(LRP5)(+)Loci: 2671 63412650-63433621 ~-21K 6988(MARK2)(+)Link out to UCSC