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0VAPB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVAPB
DescriptionVesicle-associated membrane protein-associated protein b/c (vamp- associated protein b/c) (vamp-b/vamp-c) (vap-b/vap-c).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0006461 protein complex assembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Major sperm proteins (MSP) are central components in molecular interactions underlying sperm motility in Caenorhabditis elegans.hose sperm employ an amoebae-like crawling motion using a MSP-containing lamellipod.ather than the flagellar-based swimming motion associated with other sperm. These proteins oligomerise to form an extensive filament system that extends from sperm villipoda.long the leading edge of the pseudopod. About 30 MSP isoforms may exist in C. elegans.MSPs form a fibrous network.hereby MSP dimers form helical subfilaments that coil around one another to produce filaments.hich in turn form supercoils to produce bundles. The crystal structure of MSP from C. elegans reveals an immunoglobulin (Ig)-like seven-stranded beta sandwich fold .
  IPR000535:Major sperm protein
IPR000535:Motile_Sperm 
Evalue:-42.3098030090332 
Location:6-110
SequencesProtein: VAPB_HUMAN (242 aa)
mRNA: NM_004738
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 110 residues, 56397650-56397979Exon2: 53 residues, 56426672-56426825Exon3: 36 residues, 56443063-56443167Exon4: 29 residues, 56447406-56447487Exon5: 61 residues, 56449368-56449545Exon6: 945 residues, 56452538-56455367Exon7: 2 residues, -Jump to VAPB_HUMANExon1: 69 residues, 56397774-56397979Exon2: 53 residues, 56426672-56426825Exon3: 493 residues, 56452538-56454012Exon4: 2 residues, -Jump to Q59EZ6_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3271 56397650-56455367 ~-58K 23407(VAPB)(+)Loci: 3272 56659733-56687986 ~-28K 23415(STX16)(+)Loci: 3273 56701326-56723873 ~-23K 23419(NPEPL1)(+)Loci: 3274 56989705-57003581 ~-14K 23432(TH1L)(+)Loci: 3275 57027703-57035102 ~-7K 23436(TUBB1)(+)Loci: 3270 56318176-56375966 ~-58K 23405(RAB22A)(+)Link out to UCSC