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0VAPA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameVAPA
DescriptionVesicle-associated membrane protein-associated protein a (vamp- associated protein a) (vamp-a) (vap-a) (33 kda vamp-associated protein) (vap-33).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004871 signal transducer activity (IMP)
0006944 membrane fusion (TAS)
0043123 positive regulation of I-kappaB kinase/NF-k... (IMP)
0006461 protein complex assembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Major sperm proteins (MSP) are central components in molecular interactions underlying sperm motility in Caenorhabditis elegans.hose sperm employ an amoebae-like crawling motion using a MSP-containing lamellipod.ather than the flagellar-based swimming motion associated with other sperm. These proteins oligomerise to form an extensive filament system that extends from sperm villipoda.long the leading edge of the pseudopod. About 30 MSP isoforms may exist in C. elegans.MSPs form a fibrous network.hereby MSP dimers form helical subfilaments that coil around one another to produce filaments.hich in turn form supercoils to produce bundles. The crystal structure of MSP from C. elegans reveals an immunoglobulin (Ig)-like seven-stranded beta sandwich fold .
  IPR000535:Major sperm protein
The PapD-like superfamily of periplasmic chaperones directs the assembly of over 30 diverse adhesive surface organelles that mediate the attachment of many different pathogenic bacteria to host tissues. critical early step in the development of disease. PapD.he prototypical chaperone.s necessary for the assembly of P pili. P pili contain the adhesin PapG.hich mediates the attachment of uropathogenic Escherichia coli to Gal(alpha) Gal receptors present on kidney cells and are critical for the initiation of pyelonephritis. The PapD-like chaperones consist of two Ig-like domains oriented toward each other.orming L-shaped molecules. In the chaperone-subunit complex.he G1beta strand of the chaperone completes an atypical Ig fold in the subunit by occupying the groove and running parallel to the subunit C-terminal F strand. This donor strand complementation interaction simultaneously stabilizes pilus subunits and caps their interactive surfaces.reventing their premature oligomerisation in the periplasm. During pilus biogenesis.he highly conserved N-terminal extension of one subunit has been proposed to displace the chaperone G1beta strand from its neighbouring subunit in a mechanism termed donor strand exchange .This entry represents the immunoglobulin (Ig)-like beta-sandwich domain found in PapD.s well as in other periplasmic chaperone proteins that include FimC and SfaE from Escherichia coli.nd Caf1m from Yersinia pestis . In addition.ajor sperm proteins (MSP) and other related sperm proteins (such as WR4 and SSP-19) contain an Ig-like domain with a similar structural fold to PapD . Major sperm proteins are central components in molecular interactions underlying sperm motility.ith many isoforms existing in Caenorhabditis elegans.
  IPR008962:PapD-like
IPR000535:Motile_Sperm 
Evalue:-44.6382713317871 
Location:7-111
SequencesProtein: VAPA_HUMAN (242 aa)
mRNA: NM_003574 NM_194434
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords)
KO assignmentK06096
  Level 3 annotation:
    vesicle-associated membrane protein, associated protein A
  Level 2 annotation:
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 117 residues, 9903983-9904332Exon2: 53 residues, 9921806-9921959Exon3: 36 residues, 9926106-9926210Exon4: 29 residues, 9926982-9927063Exon5: 47 residues, 9934920-9935055Exon6: 60 residues, 9940391-9940565Exon7: 1842 residues, 9944049-9949571Exon8: 2 residues, -Jump to VAPA_HUMANExon1: 117 residues, 9903983-9904332Exon2: 53 residues, 9921806-9921959Exon3: 36 residues, 9926106-9926210Exon4: 29 residues, 9926982-9927063Exon5: 60 residues, 9940391-9940565Exon6: 1842 residues, 9944049-9949571Exon7: 2 residues, -Jump to VAPA_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3055 9903983-9949571 ~-46K 17048(VAPA)(+)Loci: 3054 9698302-9852547 ~-154K 17044(RAB31)(+)Link out to UCSC