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0V1AR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAVPR1A
DescriptionVasopressin v1a receptor (v1ar) (vascular/hepatic-type arginine vasopressin receptor) (antidiuretic hormone receptor 1a) (avpr v1a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (TAS)
0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0005080 protein kinase C binding (TAS)
0005000 vasopressin receptor activity (TAS)
0008015 circulation (TAS)
0007204 elevation of cytosolic calcium ion concentr... (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0006091 generation of precursor metabolites and energy (TAS)
0007202 phospholipase C activation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Vasopressin and oxytocin are members of the neurohypophyseal hormone familyfound in all mammalian species. They are present in high levels in theposterior pituitary. Vasopressin has an essential role in the control ofthe water content of the body.cting in the kidney to increase water andsodium absorption. In higher concentrations.asopressin stimulatescontraction of vascular smooth muscle.timulates glycogen breakdown in theliver.nduces platelet activation.nd evokes release of corticotrophinfrom the anterior pituitary . Vasopressin and its analogues are usedclinically to treat diabetes insipidus.In the periphery.he V1A receptor is found in high levels in vascularsmooth muscle.yometrium and the bladder where it mediates contraction.In the CNS.1 sites are distributed widely and are found in lateral septalnucleus.ippocampus.uperior collicular.ubstantia nigra and centralgrey matter. The receptors activate phosphoinositide metabolism througha pertussis-toxin-insensitive G-protein.robably of the Gq/G11 class .
  IPR001224:Vasopressin V1A receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Vasopressin and oxytocin are members of the neurohypophyseal hormone familyfound in all mammalian species . They are present in high levels in theposterior pituitary. Vasopressin has an essential role in the control ofthe water content of the body.cting in the kidney to increase water andsodium absorption. In higher concentrations.asopressin stimulatescontraction of vascular smooth muscle.timulates glycogen breakdown in theliver.nduces platelet activation.nd evokes release of corticotrophinfrom the anterior pituitary. Vasopressin and its analogues are usedclinically to treat diabetes insipidus . Oxytocin stimulates contractionof uterine smooth muscle.nd stimulates milk secretion in response tosuckling by inducing contraction of myoepithelial cells in the mammary gland. Clinically.t is used to induce labour and promote lactation.
  IPR001817:Vasopressin receptor
IPR000276:7tm_1 
Evalue:-53.0969085693359 
Location:68-348IPR001224:VASOPRSNV1AR 
Evalue:0 
Location:29-46IPR001224:VASOPRSNV1AR 
Evalue:0 
Location:366-381IPR001224:VASOPRSNV1AR 
Evalue:0 
Location:6-21IPR001224:VASOPRSNV1AR 
Evalue:0 
Location:355-365
SequencesProtein: V1AR_HUMAN (418 aa)
mRNA: NM_000706
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK04226
  Level 3 annotation:
    arginine vasopressin receptor 1A
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 404 residues, 61826482-61827692Exon2: 983 residues, 61829913-61832857Exon3: 2 residues, -Jump to V1AR_HUMAN  
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