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0UQCR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUQCRC1
DescriptionUbiquinol-cytochrome-c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005746 mitochondrial electron transport chain (TAS)
0008121 ubiquinol-cytochrome-c reductase activity (TAS)
0009060 aerobic respiration (TAS)
0006118 electron transport (TAS)
0006119 oxidative phosphorylation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Metalloproteases are the most diverse of the four main types of protease.ith more than 30 families identified to date . In these enzymes. divalent cation.sually zinc.ctivates the water molecule. The metal ion is held in place by amino acid ligands.sually three in number. The known metal ligands are His.lu.sp or Lys and at least one other residue is required for catalysis.hich may play an electrophillic role. Of the known metalloproteases.round half contain an HEXXH motif.hich has been shown in crystallographic studies to form part of the metal-binding site . The HEXXH motif is relatively common.ut can be more stringently defined for metalloproteases as abXHEbbHbc.here a is most often valine or threonine and forms part of the S1 subsite in thermolysin and neprilysin. is an uncharged residue.nd c a hydrophobic residue. Proline is never found in this site.ossibly because it would break the helical structure adopted by this motif in metalloproteases .Peptidases are grouped into clans and families. Clans are groups of families for which there is evidence of common ancestry. Families are grouped by their catalytic type.he first character representing the catalytic type: A.spartic; C.ysteine; G.lutamic acid; M.etallo; S.erine; T.hreonine; and U.nknown. A clan that contains families of more than one type is described as being of type P. The serine.hreonine and cysteine peptidases utilise the catalytic part of an amino acid as a nucleophile and form an acyl intermediate - these peptidases can also readily act as transferases. In the case of aspartic.lutamic and metallopeptidases.he nucleophile is an activated water molecule. The majority of the sequences in this entry are metallopeptidases and non-peptidase homologs belong to MEROPS peptidase family M16 (clan ME).ubfamilies M16A.16B and M16C; they include:Insulinase.nsulin-degrading enzyme ()Mitochondrial processing peptidase alpha subunit.Alpha-MPP.Pitrlysin.rotease III precursor ()Nardilysin.)Ubiquinol-cytochrome C reductase complex core protein I.itochondrial precursor ()Coenzyme PQQ synthesis protein F ()These proteins do not share many regions of sequence similarity; the most noticeable is in the N-terminal section. This region includes a conserved histidine followed.wo residues later by a glutamate and another histidine. In pitrilysin.t has been shown that this H-x-x-E-H motif is involved in enzymatic activity; the two histidines bind zinc and the glutamate is necessary for catalytic activity.The proteins classified as non-peptidase homologues either have been found experimentally to be without peptidase activity.r lack amino acid residues that are believed to be essential for the catalytic activity.
  IPR011765:Peptidase M16, N-terminal
These metallopeptidases belong to MEROPS peptidase family M16 (clan ME). They include proteins.hich are classified as non-peptidase homologues either have been found experimentally to be without peptidase activity.r lack amino acid residues that are believed to be essential for the catalytic activity. The peptidases in this group of sequences include:Insulinase.nsulin-degrading enzyme ()Mitochondrial processing peptidase alpha subunit.Alpha-MPP.Pitrlysin.rotease III precursor ()Nardilysin.)Ubiquinol-cytochrome C reductase complex core protein I.itochondrial precursor ()Coenzyme PQQ synthesis protein F ()These proteins do not share many regions of sequence similarity; the most noticeable is in the N-terminal section. This region includes a conserved histidine followed.wo residues later by a glutamate and another histidine. In pitrilysin.t has been shown that this H-x-x-E-H motif is involved in enzymatic activity; the two histidines bind zinc and the glutamate is necessary for catalytic activity. The mitochondrial processing peptidase consists of two structurally related domains. One is the active peptidase whereas the other.he C-terminal region.s inactive. The two domains hold the substrate like a clamp .
  IPR007863:Peptidase M16, C-terminal
IPR011765:Peptidase_M16 
Evalue:-68.5228805541992 
Location:58-205IPR007863:Peptidase_M16_C 
Evalue:-43.2006607055664 
Location:210-395IPR001431:INSULINASE 
Evalue:0 
Location:0-0
SequencesProtein: UQCR1_HUMAN (480 aa)
mRNA: CR618343 NM_003365
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00414
  Level 3 annotation:
    ubiquinol-cytochrome c reductase core subunit 1
  Level 2 annotation:
    Oxidative phosphorylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 65 residues, 48611435-48611629Exon2: 27 residues, 48612071-48612147Exon3: 31 residues, 48612499-48612588Exon4: 30 residues, 48612918-48613004Exon5: 55 residues, 48613116-48613277Exon6: 50 residues, 48613411-48613555Exon7: 40 residues, 48613788-48613904Exon8: 28 residues, 48616000-48616080Exon9: 68 residues, 48616669-48616868Exon10: 45 residues, 48617087-48617217Exon11: 31 residues, 48618206-48618293Exon12: 49 residues, 48621598-48621739Exon13: 40 residues, 48621988-48622102Exon14: 2 residues, -Jump to UQCR1_HUMANExon1: 63 residues, 48611443-48611629Exon2: 27 residues, 48612071-48612147Exon3: 31 residues, 48612499-48612588Exon4: 30 residues, 48612918-48613004Exon5: 55 residues, 48613116-48613277Exon6: 50 residues, 48613411-48613555Exon7: 41 residues, 48613788-48613907Exon8: 28 residues, 48616000-48616080Exon9: 68 residues, 48616669-48616868Exon10: 45 residues, 48617087-48617217Exon11: 31 residues, 48618206-48618293Exon12: 49 residues, 48621598-48621739Exon13: 30 residues, 48621988-48622073Exon14: 2 residues, -Jump to UQCR1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4601 48530128-48569231 ~-39K 25651(PFKFB4)(-)Loci: 4602 48611435-48622102 ~-11K 25656(UQCRC1)(-)Loci: 4603 48637834-48684985 ~-47K 25658(CELSR3)(-)Loci: 4604 48686283-48698338 ~-12K 25669(NCKIPSD)(-)Loci: 4605 48762098-48860265 ~-98K 25672(-)Loci: 4606 49133551-49145603 ~-12K 25699(LAMB2)(-)Loci: 4607 49429215-49435016 ~-6K 25713(AMT)(-)Loci: 3354 49566925-49683976 ~-117K 25718(BSN)(+)Loci: 4608 49921309-49942261 ~-21K 25739(-)Loci: 4609 50330243-50333903 ~-4K 25774(HYAL2)(-)Loci: 4600 48420266-48441746 ~-21K 25634(PLXNB1)(-)Link out to UCSC