SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0UPP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUPP2
DescriptionUridine phosphorylase 2 (ec 2.4.2.3) (urdpase 2) (upase 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005829 cytosol (NAS)
0045098 type III intermediate filament (IDA)
0005515 protein binding (IDA)
0004850 uridine phosphorylase activity (IDA)
0009116 nucleoside metabolism (NAS)
0046108 uridine metabolism (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/2032252320.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The following phosphorylases belong to the same family.urine nucleoside phosphorylase () (PNP) from most bacteria (gene deoD).hich catalyzes the cleavage of guanosine or inosine torespective bases and sugar-1-phosphate molecules ; uridine phosphorylase () (UdRPase) from bacteria (gene udp) and mammals.hich catalyzes the cleavage of uridine into uracil and ribose-1-phosphate.he products of the reaction are used either as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis ; and 5-methylthioadenosine phosphorylase () (MTA phosphorylase) from Sulfolobus solfataricus . It should be noted that mammalian and some bacterial PNP as well as eukaryotic MTA phosphorylase belong to a different family of phosphorylases.
  IPR000845:Purine and other phosphorylases, family 1
This entry represents a clade of mainly eukaryotic uridine phosphorylases. Genes from human and mouse have been characterised. This enzyme is a member of the PHP/UDP subfamily and is closely related to the bacterial uridine () and inosine () phosphorylase equivalogs. In addition to the eukaryotes. gene from Mycobacterium leprae is included in this equivalog and may have resulted from lateral gene transfer.
  IPR010059:Uridine phosphorylase, eukaryotic
IPR000845:PNP_UDP_1 
Evalue:-6.76955127716064 
Location:60-308
SequencesProtein: UPP2_HUMAN (317 aa)
mRNA: NM_173355
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
KO assignmentK00757
  Level 3 annotation:
    uridine phosphorylase
  Level 2 annotation:
    Pyrimidine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 158559936-158560017Exon2: 30 residues, 158580558-158580644Exon3: 30 residues, 158666797-158666883Exon4: 41 residues, 158670856-158670974Exon5: 55 residues, 158679858-158680017Exon6: 40 residues, 158682581-158682696Exon7: 72 residues, 158686166-158686376Exon8: 51 residues, 158688506-158688653Exon9: 408 residues, 158699505-158700723Exon10: 2 residues, -Jump to UPP2_HUMAN  
Tune and view alternative isoforms