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0UCRP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameG1P2
DescriptionInterferon-induced 17 kda protein precursor .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (NAS)
0005615 extracellular space (NAS)
0005515 protein binding (NAS)
0007267 cell-cell signaling (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ubiquitin is a protein of 76 amino acid residues.ound in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. Ubiquitin acts through its post-translational attachment (ubiquitinylation) to other proteins.here these modifications alter the function.ocation or trafficking of the protein.r targets it for destruction by the 26S proteasome . The terminal glycine in the C-terminal 4-residue tail of ubiquitin can form an isopeptide bond with a lysine residue in the target protein.r with a lysine in another ubiquitin molecule to form a ubiquitin chain that attaches itself to a target protein. Ubiquitin has seven lysine residues.ny one of which can be used to link ubiquitin molecules together.esulting in different structures that alter the target protein in different ways. It appears that Lys(11)-.ys(29) and Lys(48)-linked poly-ubiquitin chains target the protein to the proteasome for degradation.hile mono-ubiquitinylated and Lys(6)- or Lys(63)-linked poly-ubiquitin chains signal reversible modifications in protein activity.ocation or trafficking . For example.ys(63)-linked poly-ubiquitinylation is known to be involved in DNA damage tolerance.nflammatory response.rotein trafficking and signal transduction through kinase activation . In addition.he length of the ubiquitin chain alters the fate of the target protein. Regulatory proteins such as transcription factors and histones are frequent targets of ubquitinylation .Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1.. ubiquitin-conjugating enzyme (E2..nd a ubiquitin ligase (E3 ).hich work sequentially in a cascade. There are many different E3 ligases.hich are responsible for the type of ubiquitin chain formed.he specificity of the target protein.nd the regulation of the ubiquitinylation process . Ubiquitinylation is an important regulatory tool that controls the concentration of key signalling proteins.uch as those involved in cell cycle control.s well as removing misfolded.amaged or mutant proteins that could be harmful to the cell. Several ubiquitin-like molecules have been discovered.uch as SUMO1 ().EDD8.ad23 ().longin B and Parkin ().he latter being involved in Parkinsons disease .
  IPR000626:Ubiquitin
IPR000626:ubiquitin 
Evalue:-21.3767509460449 
Location:86-154IPR000626:UBQ 
Evalue:-17.1804560644581 
Location:2-75
SequencesProtein: UCRP_HUMAN (164 aa)
mRNA: NM_005101
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 27 residues, 938741-938819Exon2: 185 residues, 939226-939776Exon3: 2 residues, -Jump to UCRP_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2469 938741-939776 ~-1K 23(G1P2)(+)Loci: 2470 945365-981355 ~-36K 24(AGRN)(+)Loci: 2471 1207438-1217272 ~-10K 59(SCNN1D)(+)Loci: 2472 1540746-1555847 ~-15K 98(MIB2)(+)Loci: 2473 1940702-1952050 ~-11K 141(GABRD)(+)Loci: 2474 1971768-2106692 ~-135K 142(PRKCZ)(+)Loci: 2468 885829-890958 ~-5K 15(KLHL17)(+)Link out to UCSC