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0UCP3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUCP3
DescriptionMitochondrial uncoupling protein 3 (ucp 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005743 mitochondrial inner membrane (TAS)
0005739 mitochondrion (TAS)
0005215 transporter activity (TAS)
0006629 lipid metabolism (TAS)
0015992 proton transport (TAS)
0007585 respiratory gaseous exchange (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome . Such proteins include: ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally.hese proteins can consist of up to three tandem repeats of a domain of approximately 100 residues.ach domain containing two transmembrane regions.
  IPR001993:Mitochondrial substrate carrier
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane . Such proteins include: ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mito- chondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others.The brown fat uncoupling protein (UCP) dissipates oxidative energy into heatby transporting protons from the cytosol into the mitochondrial matrix .UCP functions as a dimer.orming a proton channel that leads to uncouplingof oxidative phosphorylation by dissipation of the electrochemical potentialacross the inner membrane.The protein has a tripartite structure.ith 3 similar ~100 residue domains.The domains exhibit striking conservation of several residues.speciallyof glycine and proline.hich may constitute structurally strategicpositions . The protein is thought to contain 6 transmembrane helices. These characteristics are shared by the ADP/ATP carrier protein.hichis a member of the mitochondrial carrier family.
  IPR002030:Mitochondrial brown fat uncoupling protein
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varying degrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being about 100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R) {where - denotesany residue.nd Hy is a hydrophobic position} .
  IPR002067:Mitochondrial carrier protein
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (orcitrate transport protein); Graves disease carrier protein; yeastmitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varyingdegrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being ~100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R){where - denotesany residue.nd Hy is a hydrophobic position} .Mitochondrial ADP/ATP translocase.n abundant component of the innermembrane.arries ATP from the matrix into the inter-membrane space andtransports ADP back . The protein is an integral membrane protein thatfunctions as a homodimer.
  IPR002113:Adenine nucleotide translocator 1
IPR001993:Mito_carr 
Evalue:-34.3872146606445 
Location:115-211IPR001993:Mito_carr 
Evalue:-29.7447280883789 
Location:216-305IPR001993:Mito_carr 
Evalue:-23.3665313720703 
Location:12-110
SequencesProtein: UCP3_HUMAN (312 aa)
mRNA: NM_003356
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 412 residues, 73388984-73390219Exon2: 62 residues, 73392519-73392700Exon3: 36 residues, 73393176-73393278Exon4: 70 residues, 73394422-73394626Exon5: 72 residues, 73394861-73395072Exon6: 75 residues, 73395609-73395830Exon7: 38 residues, 73397670-73397778Exon8: 2 residues, -Jump to UCP3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3972 73388984-73397778 ~-9K 7384(UCP3)(-)Loci: 3973 73423126-73492291 ~-69K 7386(-)Loci: 3971 73064337-73149849 ~-86K 7373(RAB6A)(-)Link out to UCSC