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0UBE3A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUBE3A
DescriptionUbiquitin-protein ligase e3a (ec 6.3.2.-) (e6ap ubiquitin-protein ligase) (oncogenic protein-associated protein e6-ap) (human papillomavirus e6-associated protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004840 ubiquitin conjugating enzyme activity (TAS)
0007420 brain development (TAS)
0006508 proteolysis and peptidolysis (TAS)
0006511 ubiquitin-dependent protein catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The name HECT comes from Homologous to the E6-AP Carboxyl Terminus . Proteins containing this domain at the C-terminus includeubiquitin-protein ligase.hich regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester.nd then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interactingprotein 12.hich also contains this domain.s a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediatedproteolysis.
  IPR000569:HECT
IPR000569:HECTc 
Evalue:-179.309803919971 
Location:545-875
SequencesProtein: UBE3A_HUMAN (875 aa)
mRNA: NM_000462
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentK01932
  Level 3 annotation:
    
  Level 2 annotation:
    Tryptophan metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 670 residues, 23133489-23135497Exon2: 50 residues, 23136324-23136468Exon3: 26 residues, 23150592-23150666Exon4: 54 residues, 23150767-23150923Exon5: 57 residues, 23152131-23152296Exon6: 70 residues, 23152930-23153136Exon7: 50 residues, 23156622-23156767Exon8: 417 residues, 23166805-23168052Exon9: 101 residues, 23171704-23172003Exon10: 16 residues, 23201700-23201742Exon11: 11 residues, 23204859-23204888Exon12: 2 residues, -Jump to UBE3A_HUMAN  
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