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0UB7I3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionUbiquitin conjugating enzyme 7 interacting protein 3 (hepatitis b virus x-associated protein 4) (hbv-associated factor 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ran is an evolutionary conserved member of the Ras superfamily that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran binding protein 2 (RanBP2) is a 358-kDa nucleoporin located on the cytoplasmic side of the nuclear pore complex which plays a role in nuclear protein import . RanBP2 contains multiple zinc fingers which mediate binding to RanGDP .
  IPR001876:Zinc finger, RanBP2-type
Quality control of intracellular proteins is essential for cellular homeostasis. Molecular chaperones recognise and contribute to the refolding of misfolded or unfolded proteins.hereas the ubiquitin-proteasome system mediates the degradation of such abnormal proteins. Ubiquitin-protein ligases (E3s) determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. More recently.owever.-box proteins.hich contain a domain (the U box) of about 70 amino acids that is conserved from yeast to humans.ave been identified as a new type of E3 .The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc.nd is probably involved in mediating protein-protein interactions. . There are two different variants.he C3HC4-type and a C3H2C3-type.hich is clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as RING-H2 finger. The RING domain is a protein interaction domain which has been implicated in a range of diverse biological processes.E3 ubiquitin-protein ligase activity is intrinsic to the RING domain ofc-Cbl and is likely to be a general function of this domain; Various RINGfingers exhibit binding to E2 ubiquitin-conjugating enzymes (Ubcs) .Several 3D-structures for RING-fingers are known . The 3D structure of the zinc ligation system is unique to the RING domain and is referred to as the cross-brace motif. The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion.hilst pairs two and four bind the second.s illustrated in the following schematic representation:Note that in the older literature.ome RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family.lbeit with similar Cys-spacing (see ).
  IPR001841:Zinc finger, RING-type
SequencesProtein: UB7I3_HUMAN (500 aa)
mRNA: NM_031229
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 223 residues, 336755-337423Exon2: 50 residues, 338524-338669Exon3: 33 residues, 346169-346263Exon4: 68 residues, 346375-346574Exon5: 42 residues, 347990-348112Exon6: 60 residues, 348201-348375Exon7: 55 residues, 349514-349675Exon8: 39 residues, 350770-350882Exon9: 62 residues, 355956-356136Exon10: 35 residues, 357134-357233Exon11: 50 residues, 357594-357738Exon12: 207 residues, 358993-359608Exon13: 2 residues, -Jump to UB7I3_HUMAN  
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Loci Cluster (Details)Loci: 3226 336755-359608 ~-23K 22500(UBCE7IP3)(+)Loci: 4505 411337-472482 ~-61K 22506(CSNK2A1)(-)Loci: 3225 309307-326201 ~-17K 22496(TRIB3)(+)Link out to UCSC