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0UB2V1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUBE2V1
DescriptionUbiquitin-conjugating enzyme e2 variant 1 (uev-1) (croc-1) (ubiquitin- conjugating enzyme variant kua) (traf6-regulated ikk activator 1 beta uev1a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0016563 transcriptional activator activity (TAS)
0004840 ubiquitin conjugating enzyme activity (TAS)
0030154 cell differentiation (NAS)
0000209 protein polyubiquitination (TAS)
0006282 regulation of DNA repair (TAS)
0000074 regulation of progression through cell cycle (TAS)
0006355 regulation of transcription, DNA-dependent (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The post-translational attachment of ubiquitin () to proteins (ubiquitinylation) alters the function.ocation or trafficking of a protein.r targets it to the 26S proteasome for degradation . Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1.. ubiquitin-conjugating enzyme (E2).nd a ubiquitin ligase (E3 ).hich work sequentially in a cascade . The E1 enzyme mediates an ATP-dependent transfer of a thioester-linked ubiquitin molecule to a cysteine residue on the E2 enzyme. The E2 enzyme () then either transfers the ubiquitin moiety directly to a substrate.r to an E3 ligase.hich can also ubiquitinylate a substrate.There are several different E2 enzymes (over 30 in humans).hich are broadly grouped into four classes.ll of which have a core catalytic domain (containing the active site cysteine).nd some of which have short N- and C-terminal amino acid extensions: class I enzymes consist of just the catalytic core domain (UBC).lass II possess a UBC and a C-terminal extension.lass III possess a UBC and an N-terminal extension.nd class IV possess a UBC and both N- and C-terminal extensions. These extensions appear to be important for some subfamily function.ncluding E2 localisation and protein-protein interactions . In addition.here are proteins with an E2-like fold that are devoid of catalytic activity.ut which appear to assist in poly-ubiquitin chain formation.
  IPR000608:Ubiquitin-conjugating enzyme, E2
IPR000608:UBQ-conjugat_E2 
Evalue:-41.6777801513672 
Location:81-219IPR000608:UBIQUITIN_CONJUGAT_1 
Evalue:0 
Location:0-0
SequencesProtein: UB2V1_HUMAN (221 aa)
mRNA: NM_003349 NM_199203
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 597 residues, 48131069-48132858Exon2: 44 residues, 48134072-48134198Exon3: 51 residues, 48146615-48146764Exon4: 73 residues, 48177918-48178131Exon5: 35 residues, 48179489-48179589Exon6: 2 residues, -Jump to UB2V1_HUMANExon1: 597 residues, 48131069-48132858Exon2: 44 residues, 48134072-48134198Exon3: 51 residues, 48146615-48146764Exon4: 73 residues, 48177918-48178131Exon5: 50 residues, 48179489-48179634Exon6: 32 residues, 48180799-48180891Exon7: 42 residues, 48193445-48193565Exon8: 71 residues, 48203460-48203667Exon9: 2 residues, -Jump to UB2V1_HUMAN  
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Loci Cluster (Details)Loci: 4529 48131069-48203667 ~-73K 23328(UBE2V1)(-)Loci: 3264 47862656-47942179 ~-80K 23321(SLC9A8)(+)Link out to UCSC