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0UB2L3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUBE2L3
DescriptionUbiquitin-conjugating enzyme e2 l3 (ec 6.3.2.19) (ubiquitin-protein ligase l3) (ubiquitin carrier protein l3) (ubch7) (e2-f1) (l-ubc).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000151 ubiquitin ligase complex (TAS)
0019899 enzyme binding (TAS)
0004840 ubiquitin conjugating enzyme activity (TAS)
0004842 ubiquitin-protein ligase activity (TAS)
0006464 protein modification (TAS)
0006511 ubiquitin-dependent protein catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The post-translational attachment of ubiquitin () to proteins (ubiquitinylation) alters the function.ocation or trafficking of a protein.r targets it to the 26S proteasome for degradation . Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1.. ubiquitin-conjugating enzyme (E2).nd a ubiquitin ligase (E3 ).hich work sequentially in a cascade . The E1 enzyme mediates an ATP-dependent transfer of a thioester-linked ubiquitin molecule to a cysteine residue on the E2 enzyme. The E2 enzyme () then either transfers the ubiquitin moiety directly to a substrate.r to an E3 ligase.hich can also ubiquitinylate a substrate.There are several different E2 enzymes (over 30 in humans).hich are broadly grouped into four classes.ll of which have a core catalytic domain (containing the active site cysteine).nd some of which have short N- and C-terminal amino acid extensions: class I enzymes consist of just the catalytic core domain (UBC).lass II possess a UBC and a C-terminal extension.lass III possess a UBC and an N-terminal extension.nd class IV possess a UBC and both N- and C-terminal extensions. These extensions appear to be important for some subfamily function.ncluding E2 localisation and protein-protein interactions . In addition.here are proteins with an E2-like fold that are devoid of catalytic activity.ut which appear to assist in poly-ubiquitin chain formation.
  IPR000608:Ubiquitin-conjugating enzyme, E2
IPR000608:UQ_con 
Evalue:-64.6777801513672 
Location:6-144
SequencesProtein: UB2L3_HUMAN (154 aa)
mRNA: NM_003347
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 35 residues, 20251956-20252060Exon2: 34 residues, 20277149-20277245Exon3: 64 residues, 20295145-20295332Exon4: 842 residues, 20305803-20308323Exon5: 2 residues, -Jump to UB2L3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3301 20326541-20328587 ~-2K 24274(SDF2L1)(+)Loci: 4561 20443948-20551970 ~-108K 24279(MAPK1)(-)Loci: 3300 20251956-20308323 ~-56K 24268(UBE2L3)(+)Link out to UCSC