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0UB2E1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUBE2E1
DescriptionUbiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0004840 ubiquitin conjugating enzyme activity (TAS)
0004842 ubiquitin-protein ligase activity (TAS)
0006511 ubiquitin-dependent protein catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The post-translational attachment of ubiquitin () to proteins (ubiquitinylation) alters the function.ocation or trafficking of a protein.r targets it to the 26S proteasome for degradation . Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1.. ubiquitin-conjugating enzyme (E2).nd a ubiquitin ligase (E3 ).hich work sequentially in a cascade . The E1 enzyme mediates an ATP-dependent transfer of a thioester-linked ubiquitin molecule to a cysteine residue on the E2 enzyme. The E2 enzyme () then either transfers the ubiquitin moiety directly to a substrate.r to an E3 ligase.hich can also ubiquitinylate a substrate.There are several different E2 enzymes (over 30 in humans).hich are broadly grouped into four classes.ll of which have a core catalytic domain (containing the active site cysteine).nd some of which have short N- and C-terminal amino acid extensions: class I enzymes consist of just the catalytic core domain (UBC).lass II possess a UBC and a C-terminal extension.lass III possess a UBC and an N-terminal extension.nd class IV possess a UBC and both N- and C-terminal extensions. These extensions appear to be important for some subfamily function.ncluding E2 localisation and protein-protein interactions . In addition.here are proteins with an E2-like fold that are devoid of catalytic activity.ut which appear to assist in poly-ubiquitin chain formation.
  IPR000608:Ubiquitin-conjugating enzyme, E2
IPR000608:UQ_con 
Evalue:-75.3372421264648 
Location:51-188
SequencesProtein: UB2E1_HUMAN (193 aa)
mRNA: NM_003341
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 48 residues, 23822442-23822583Exon2: 63 residues, 23823731-23823916Exon3: 19 residues, 23827954-23828005Exon4: 46 residues, 23904061-23904194Exon5: 51 residues, 23905606-23905754Exon6: 269 residues, 23907003-23907806Exon7: 2 residues, -Jump to UB2E1_HUMAN  
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Loci Cluster (Details)Loci: 3341 23933642-23937334 ~-4K 25306(RPL15)(+)Loci: 3340 23822442-23907806 ~-85K 25303(UBE2E1)(+)Link out to UCSC