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0UB2D3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameUBE2D3
DescriptionUbiquitin-conjugating enzyme e2 d3 (ec 6.3.2.19) (ubiquitin-protein ligase d3) (ubiquitin carrier protein d3) (ubiquitin-conjugating enzyme e2-17 kda 3) (e2(17)kb 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The post-translational attachment of ubiquitin () to proteins (ubiquitinylation) alters the function.ocation or trafficking of a protein.r targets it to the 26S proteasome for degradation . Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1.. ubiquitin-conjugating enzyme (E2).nd a ubiquitin ligase (E3 ).hich work sequentially in a cascade . The E1 enzyme mediates an ATP-dependent transfer of a thioester-linked ubiquitin molecule to a cysteine residue on the E2 enzyme. The E2 enzyme () then either transfers the ubiquitin moiety directly to a substrate.r to an E3 ligase.hich can also ubiquitinylate a substrate.There are several different E2 enzymes (over 30 in humans).hich are broadly grouped into four classes.ll of which have a core catalytic domain (containing the active site cysteine).nd some of which have short N- and C-terminal amino acid extensions: class I enzymes consist of just the catalytic core domain (UBC).lass II possess a UBC and a C-terminal extension.lass III possess a UBC and an N-terminal extension.nd class IV possess a UBC and both N- and C-terminal extensions. These extensions appear to be important for some subfamily function.ncluding E2 localisation and protein-protein interactions . In addition.here are proteins with an E2-like fold that are devoid of catalytic activity.ut which appear to assist in poly-ubiquitin chain formation.
  IPR000608:Ubiquitin-conjugating enzyme, E2
IPR000608:UQ_con 
Evalue:-78.6197891235352 
Location:5-142
SequencesProtein: UB2D3_HUMAN (147 aa)
mRNA: NM_181886
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 495 residues, 103936217-103937701Exon2: 33 residues, 103939675-103939769Exon3: 37 residues, 103941720-103941826Exon4: 28 residues, 103942827-103942905Exon5: 12 residues, 103949939-103949971Exon6: 23 residues, 103950059-103950123Exon7: 122 residues, 103966776-103967136Exon8: 122 residues, 103967883-103968243Exon9: 2 residues, -Jump to UB2D3_HUMAN  
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